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gibbons everlasting…

… it keeps turning up like a bad penny The Internet tells me that this phrase comes from 18th century England [when a penny was serious money]. Pennies were frequently counterfeited in those times. So if if one turned up in one’s purse, it was spent quickly. There were so many in circulation that you […]

thanks to Robert Gibbons…

Clinical Trials of various sorts are intended to be the final word in evaluating both the safety and the efficacy of medications. In psychiatry, they’re more complicated because the outcome parameters are from the subjective reporting of either observers or subjects converted to objective data by rating forms and checklists. Unfortunately, they’ve moved to center […]

more Gibbons…

The current Psychiatric Times has an odd article on a familiar topic, Robert Gibbons latest assault on the FDA Black Box Warning about suicidality in children and adolescents on antidepressants [an anatomy of deceit…]. These Gibbons papers [Suicidal Thoughts and Behavior With Antidepressant Treatment, Benefits From Antidepressants] have been reviewed here ad nauseum. They purport […]

gibbons unplugged…

i wonder

Test-Retest Reliability of a Computerized Adaptive Depression Screener by David Beiser, Milkie Vu, and Robert Gibbons Psychiatric Services. Published online: April 15, 2016 Objective: Computerized adaptive testing [CAT] provides improved precision and decreased test burden compared with traditional, fixed-length tests. Concerns have been raised regarding reliability of CAT-based measurements because the items administered vary both […]

smoke screens…

Editorial US Preventive Services Task Force Recommendation Statement on Screening for Depression in Adults Not Good Enough by Charles F. Reynolds III, MD and Ellen Frank, PhD JAMA Psychiatry. 2016 73[3]:189-190. The US Preventive Services Task Force [USPSTF] has recommended screening for depression in the general adult population, including pregnant and postpartum women, with the […]

an innovative design…

It has been quite a week, so I haven’t had much else on my mind outside of our own publication [Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence], but I ran across this paper and thought it was pretty interesting – focused on a topic that’s […]

the Age of the Decepticons…

The Treatment for Adolescents with Depression Study [TADS] was an NIMH funded clinical trial including 439 adolescents that ran from September 1998 though March 2004. The study compared Placebo [PBO], Prozac [FLX], Cognitive Behavior Therapy [CBT], and Prozac+Cognitive Behavior Therapy [COMBO] for 12 weeks in a blinded RCT. But that’s not all folks.  They then […]

the fiction – and another thing…

The Relationship Between Antidepressant Initiation and Suicide Risk Special Reports, Psychopharmacology, Suicide Psychiatric Times By Robert D. Gibbons, PhD and J. John Mann, MD December 31, 2014 [full text on-line with free registration] There has been much debate about whether certain classes of medications [eg, antidepressants] increase the risk of suicidal behavior and whether that […]

the fiction…

University of Chicago Statistician Robert Gibbons was a voting consultant on the 2004 FDA Pediatric Advisory Committee that elected to add the Black Box Warning to the labeling of the Antidepressants: Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children and adolescents in short-term studies of major depressive disorder […]