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Archive for October, 2012

humility…

[click image for full schedule] So the APA Board of Trustees gives the final go ahead to send the DSM-5 to the printers at one of those highlighted meetings up there, either next week or in another month, and open themselves up to making a really tragic mistake. They are walking into approving a DSM […]

naked!…

The British Medical Journal announcement that they will not consider publishing Clinical Trials without full patient level data is ever so welcome here in 1boringoldmanville [God Save the Queen!…]. Ever since GSK announced it would make data available by approval of an independent panel [need to hear more…], I find myself seeing loopholes – ways […]

God Save the Queen!…

Some days, it’s a pleasure to wake up and read the news. This is one of them… British Medical Journal moves to flush out secret trial data Reuters Oct 31, 2012 The respected British Medical Journal (BMJ) will refuse to publish research papers on drugs unless the clinical trial data behind these studies is made […]

“but this is ridiculous”…

Reading this blog, it might be easy to forget that I’m a psychiatrist, because I’m so often criticizing something about the current state of affairs in psychiatry. But this particular criticism is more fundamental. In the usual blog, I’m looking for scientific misbehavior driven in most instances by misguided alliances. In this case, an official […]

finally…

Well, they finally published the results of the DSM-5 Field Trials. Here are the links to the abstracts and a forest plot of kappa values to look over: DSM-5 Field Trials in the United States and Canada, Part I: Study Design, Sampling Strategy, Implementation, and Analytic Approaches by Diana E. Clarke, William E. Narrow, Darrel […]

part of the problem…

It’s fashionable these days for people to say "there are no coincidences" and give meaningful looks when something uncanny happens, implying some unexplained but vaguely spiritual connection. I’m not much of a supernatural type. The natural world is more than enough for me to handle. But this morning when I sat down at the computer […]

yikes…

We returned from a long weekend in the North Carolina mountains and like most have been glued to the Weather Channel as the winds howled in the trees here in North Georgia with enough power to send limbs flying and knock out our power for a while. It was hard to imagine that the winds […]

what were they thinking? fruit flies

Neuroscience, Clinical Evidence, and the Future of Psychiatric Classification in DSM-5 by David J. Kupfer, M.D. and Darrel A. Regier, M.D., M.P.H. American Journal of Psychiatry 168:672-674, 2011. In the initial stages of development of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders, we expected that some of the limitations of […]

52% improvement…

Just in passing, this ad flashed before me: and I saw 52% improvement out of the corner of my eye. So I went back and looked. It’s 52% improvement in the the HAM-D17 score over 8 weeks as opposed to a 43% improvement of the placebo group over the same interval resulting in a 2 […]

GGG…

Antidepressant Study Stirs Controversy Medscape Medical News > Psychiatry by Fran Lowry Oct 22, 2012 A recent meta-analysis concluding that 2 antidepressants neither increased nor decreased suicidal thoughts and behavior in children is flawed, Harvard researchers say. However, the authors of the study stand by their article and its conclusion.  The study, led by Robert Gibbons, PhD, […]