from the land of Monty Python…

Posted on Monday 1 October 2012

Back in the Spring, I was writing about the flurry of activity when the news of PHARMA’s exodus from CNS drug development hit, and I ran across a speech by British Neuropsychopharmacologist, Dr. David Nutt, at the Royal College of Psychiatry in June 2011 that antedated the more recent flurry of lamentations [No Psychiatry Without Psychopharmacology]. Following up on Dr. Nutt, I found this [suddenly, last summer…]:
There is an irony in this story. Dr. Nutt himself was a truth-sayer. In 2008, he became Chairman of the  Advisory Council on the Misuse of Drugs. He was an outspoken advocate for basing the laws about street drugs on their true evidence-based dangers – publishing this graph in The Lancet:


[click image for the link]

In 2009, Dr. Nutt was fired from this appointment because of his own truth-saying about Street Drugs [and one has to wonder where the prescription medications Nutt both promotes and defends would fall on his own graph].
That last bit of sarcasm came because at the time I was writing the above, I was becoming acutely aware of how difficult and intractable the withdrawal syndromes from some of the modern psychotherapeutic agents could be.

I’m sure I’m not the first person to wonder about the relationship between the sixties’ drug culture and the later preoccupation of psychiatry with psychopharmacology, so I found Nutt’s position interesting. He is a past president of the British Association of Psychopharmacology and of the European College of Neuropsychopharmacology. He is the president of the British Neuroscience Association and vice-president of the European Brain Council. Dr. Nutt hardly has the look and feel of a latter-day hippie.

That story occasionally occurs to me when I read about medical Marijuana or about the use of Ketamine in the treatment of depression – the interface between these drug cultures. But I wasn’t quite prepared for this – Dr. Nutt’s appearance on British television testing the drug Ecstasy [MDMA] in celebrity volunteers, complete with fMRI. One episode of a two part series has shown and the other is on soon. A few links:
I pass it on because it’s there. The pipeline might really be that empty…

UPDATE: And the beat goes on. Is he onto something? or on something?

David Nutt, a prominent and often controversial investigator at Imperial College London, has landed about $800,000 from the U.K.’s Medical Research Foundation to test the active ingredient in "magic mushrooms" as a possible new treatment for depression. Working with the knowledge that psilocybin has been linked to long-term relief for cases of serious depression, Nutt has lined up a manufacturer able to produce a dose that can be injected in about 30 patients. Investigators will take brain scans of the volunteers to help determine how the therapy works.

Three years ago, Nutt was bounced out of his role as chairman of the U.K. government’s advisory council on drugs after making some controversial remarks on the relative dangers of ecstasy. And it hasn’t been easy getting to this stage of his work on psilocybin, relying heavily on help from supporters. Even if the drugs works in the trial, there’s a major hurdle between his treatment and any kind of marketed product: It’s an illegal substance. "One of the things to change in parallel with the trial is the law," he told The Financial Times. "Otherwise the big problem is if it works, no one will be able to prescribe it."

 
  1.  
    October 1, 2012 | 5:20 PM
     

    Ah. Discontinuation Syndrome. That’s when a person’s brain has adapted to a drug so that when the drug is discontinued the brain needs time to adapt to the lack of the drug; which is— I’m sure of it— withdrawal from a drug that one is addicted to.

  2.  
    October 1, 2012 | 8:19 PM
     

    Monty Python might have consulted on naming the European College of Neuropsychopharmacology.

    The idea of ketamine as a therapeutic agent always makes me laugh. But then, giving legal speed to children and then decrying their trading it in college — oh, how the drug culture has changed.

Sorry, the comment form is closed at this time.