postcards from the grave…

Posted on Tuesday 8 January 2013


he·gem·o·ny [hj-mn]
  noun
    1: preponderant influence or authority over others: domination
    2: the social, cultural, ideological, or economic influence exerted by a dominant group

Psychiatry is approaching a crisis. For thirty years, it has been dominated by the inertia of the coup d’etat in 1980, the DSM-III revision that became a virtual Declaration of Independence from its domination by a small but powerful subgroup – the psychoanalysts. While claiming to redefine its own destiny, it has been increasingly shaped by other powerful forces – the Insurance/Hospital Industries in a variety of incarnations and the well-heeled Pharmaceutical Industry, soon to be joined by an emerging third power – the government.

Like the Star Wars series or the cowboy movies which take place primarily in systems at the edge of the things, psychiatry has always operated at the outer rim of the medical galaxy – dealing, as we do, with the most complex and least understandable of organ systems. The analysts had their shot at the software side followed now by the biologists who focused on the hardware. But what we still don’t know about both is painfully clear to us all [and everyone else] – keeping us wandering in the wilderness prey to the chaos of a frontier culture. While that makes for excellent fiction, it’s a difficult and volatile academic enterprise and we have recurrent he·gem·o·ny problems.

Last week, I blogged about articles on Medscape by two of our most prominent leaders, Dr. Jefferey Leiberman, president elect of the American Psychiatric Association, and Dr. David Kupfer, leader of the DSM-5 Task Force, a code book often referred to as the the ‘Bible’ of psychiatry. Both were defending the industry connections of our leaders. From Dr. Lieberman:
… but the fact of the matter is that this does not mean that the academic medical community and physician investigators should not or cannot be actively involved collaboratively in the drug discovery and development process. Indeed, this type of interaction and collaboration is not just helpful but is essential if we are going to sustain medical progress in developing treatments for human disease…
and from Dr. Kupfer:
"When we established the limits on income from industry sources, we looked to make them more stringent than requirements for staff at the National Institutes of Health, members of advisory committees for the Food and Drug Administration, and most academic departments," he answered. Dr. Kupfer added that each member agreed to follow these limits at the start of their work on DSM-5 — and to continue following them as long as they are involved in the development of the manual. "APA has looked to strengthen these policies even further for new clinical practice guidelines in development…"
No one is arguing about academic psychiatrists having some input into the development of psychiatric medications by the pharmaceutical industry. What we’re screaming about is things going the other way – the pharmaceutical industry having input into the power structure and expert opinions of academic psychiatrists! And that’s an elementary observation easily made by these smart guys – they know what we’re saying already. It’s not about information, it’s about marketing and money. Dr. Kupfer acts as though a temporary limitations on the flow of dough to the DSM-5 Task Force members is adequate. It’s the opposite, a ruse. And Lieberman’s point about being involved in drug discovery evades the malignant epidemic of conflicts of interest in the ranks of the APA. His own N.I.M.H. study, C.A.T.I.E., invalidated the message of a hoard of KOLs who were virtual evangelists for the wonders of the Atypical Antipsychotics. Didn’t he read it and then look back at the literature that came before! And then he signed on to the industry financed C.A.F.E. study which tried to soften his own findings. What’s wrong with this thinking? [see comments here and here].

I’m reminded of my Dad’s saying, "I don’t mind you peeing in my boot, but don’t tell me it’s water." He had another favorite, "If you’re not going to do it right, don’t do it at all." Both seem to fit. Enough already with the frontier fiction…

Update: Duane’s Mom weighs in, “You made the mess… You clean it up.
  1.  
    jamzo
    January 8, 2013 | 1:09 PM
     

    this op-ed posting on Pharamlot much related to your current discussion of academic leaders in psychiatry …the op-ed is recommending changes to Pharma marketing strategies….i have cut and pasted a relevant recommendation below

    ” • Effective launch strategies focus not just on tracking, understanding and targeting the physicians who write the script. They must also focus on a much broader group of people who influence the script—including patient advocates and social media KOLs, such as conference speakers and specialists. The key to success is to build a robust KOL network that extends beyond the top 20 most well known national KOLs into the top 100 regional and local KOLs as well. “

  2.  
    jamzo
    January 8, 2013 | 1:10 PM
     

    my bad! i neglected to include the link to the pharma op-ed post that i cited.

    http://www.pharmalot.com/2013/01/the-op-ed-a-paradigm-shift-in-launching-drugs/

  3.  
    January 8, 2013 | 3:04 PM
     

    So when someone says, “I don’t think these connections create any bias” it means – ‘I’m not willing to think about the bias that these connections create’ which is a red flag that they won’t be recognised or addressed.

    We’re all susceptible to them. The trick is to recognise they exist and put measures in place to account for them.

    Sadly, it doesn’t look like this has happened with the DSM-5.

    http://mindhacks.com/2012/12/30/a-depressing-financial-justification/

  4.  
    January 8, 2013 | 5:18 PM
     

    My dad gave me the same advice about doing things right.
    From my mom, “You made the mess… You clean it up.”

    Psychiatry apparently had some poor parenting.

    Duane

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