DSM-5 retrospective III…

Posted on Friday 3 January 2014

No retrospective of the DSM-5 process would be complete without a commentary from the summer of 2009, when things moved into the public arena. And there’s no better ringside commentator than Danny Carlat who was blogging the whole thing blow by blow. Senator Grassley’s Investigation was still in the news, and a few weeks before, Dr. Nemeroff’s pal Zach Stowe had been fingered for committing the same sins as his boss – unreported income for speaker gigs while on a grant from GSK. All hell broke loose when Allen Frances went public:
The Carlat Psychiatry Blog
by Danny Carlat
June 30, 2009

Psychiatry’s diagnostic manual is due for a revision. But what began as a group of top scientists reviewing the research literature has degenerated into a dispute that puts the Hatfield-McCoy feud to shame. The latest installment in this remarkable episode of American psychiatry involves an editorial by Dr. Allen Frances, the chairman of the committee that created the current version of the the DSM, the DSM-IV. The editorial has not even been officially published [it is in press at Psychiatric Times] but already it has made the rounds of the blogs and is being read and debated widely. Now, the APA has just released this rather stunning response
First, Carlat summarizes Dr. Frances’ criticisms of the developing DSM-5 [we know the back story from Greenberg’s 2010 article in Wired].
In his editorial, Dr. Frances criticizes the evolving DSM-V on multiple levels, and makes the following claims:
• The process of writing the manual is less transparent and less inclusive than the process he oversaw when he chaired the DSM-IV committee.
• The underlying science of psychiatry has not advanced enough to merit the kind of extreme makeover proposed by the DSM-V chairpeople:
    "The simple truth is that descriptive psychiatric diagnosis does not need and cannot support a paradigm shift. There can be no dramatic improvements in psychiatric diagnosis until we make a fundamental leap in our understanding of what causes mental disorders. The incredible recent advances in neuroscience, molecular biology, and brain imaging that have taught us so much about normal brain functioning are still not relevant to the clinical practicalities of everyday psychiatric diagnosis. The clearest evidence supporting this disappointing fact is that not even one biological test is ready for inclusion in the criteria sets for DSM-5."
• The main change being proposed—the official inclusion of a series of rating scales into the diagnostic criteria—is poorly conceived because busy clinicians will reject this extra paper-work.
• Other proposed changes in DSM-V will make it too easy to over-diagnose a range of conditions:
    “The result would be a wholesale imperial medicalization of normality that will trivialize mental disorder and lead to a deluge of unneeded medication treatment–a bonanza for the pharmaceutical industry but at a huge cost to the new false positive "patients" caught in the excessively wide DSM-V net. They will pay a high price in side effects, dollars, and stigma, not to mentions the unpredictable impact on insurability, disability, and forensics.”
Frances’ article is compelling, not only because of the substance of his arguments but because of his clear and forceful writing style. With each sentence, you get a sense that this man has carefully thought through all of these issues and is passionately concerned about the future of his field.
All familiar: Secrecy, an unwarranted paradigm shift, superfluous rating scales, and the medicalization of normality with overdiagnosis and overmedication. Then Carlat summarizes the APA response from Alan Schatzberg, David Kupfer, Darrell Regier, and James Scully, which ends with:
“Both Dr. Frances and Dr. Spitzer have more than a personal “pride of authorship” interest in preserving the DSM-IV and its related case book and study products. Both continue to receive royalties on DSM-IV associated products. The fact that Dr. Frances was informed at the APA Annual Meeting last month that subsequent editions of his DSM-IV associated products would cease when the new edition is finalized, should be considered when evaluating his critique and its timing.”
Now look at the response to Dr. Carroll’s comments about the CAT-DI test signed by Robert D. Gibbons, David Weiss, Paul Pilkonis, Ellen Frank, Tara Moore, Jong Bae Kim, and David Kupfer [see insider trading…]:
"It is, however, completely unclear that his lack of enthusiasm is based on any scientifically rigorous foundation. Indeed, his knowledge of these methods seems lacking. Finally, Carroll is quick to point out the acknowledged potential conflicts of others as if they have led to bias in reporting of scientific information. In this case, it is Carroll who has the overwhelming conflict of interest. As developer, owner, and marketer of the Carroll Depression Scale–Revised, a traditional fixed-length test, it is not surprising that the paradigm shift described in our article would be of serious concern to him."
This latter response came before we knew of their commercial enterprise and the obvious COI for Drs. Kupfer and Frank.

In our military, we have an article, Article 113: Conduct Unbecoming an Officer and a Gentleman [shortened now to Conduct Unbecoming an Officer]. Uncharacteristically, considering the usual military penchant for details, it’s very loosely defined. We don’t need a definition, because we all know what it means. It refers to the fact that we hold our leaders to a higher standard of conduct than the simple standards of the civil and criminal laws. There’s a similar implicit standard in Medicine.

This era of the DSM-5 Revision spans the manipulative logic of A Research Agenda for the DSM-V through the response to Drs. Spitzer and Frances complaints to this recent reaction to the revelations about Drs. Gibbons and Kupfer and their opening salvo in response. There’s only one name that’s on all three documents – David Kupfer. There have been equally disturbing parallels throughout the the same time frame in the conduct of the psychiatric leadership, all well known to us all. The problems in psychiatry are not ideological, they’re Article 113 problems in our leadership, and the DSM-5 process is a paradigmatic example…
  1.  
    wiley
    January 3, 2014 | 2:50 PM
     

    “Other proposed changes in DSM-V will make it too easy to over-diagnose a range of conditions:” which would be in a addition to the changes that were made in the DSM-4 that made it too easy to over-diagnose a range of conditions.

  2.  
    January 3, 2014 | 2:53 PM
     

    Quite the post series you have going here, Dr Mickey. But the question I hope is somewhat explored or pressed to be pursued by authorities of power and consequences is simply this: Will the APA face fall out for efforts flagrantly detrimental to the public?

    The only way criminality is at least curbed is to watch their own be caught and be punished. Won’t end the mockery of “clinical care” the APA claims to be offering, but, some might step back and maybe even back out from further nefarious agendas.

    I like to see bad things happen to bad people. Karma is a bitch, and I love watching the criminal get slapped. Hard!

    It’s the only way the profession has a chance to restore itself. But, as long as there are entrenched membership holders to the APA, it is like the Sith, there will always be another apprentice to train…

  3.  
    Bernard Carroll
    January 3, 2014 | 3:09 PM
     

    Article 113 is a very appropriate reference here. And you are right, conduct unbecoming an officer doesn’t need a close definition – we recognize it when we see it. One response to conduct unbecoming is impeachment. We need to use it more often.

  4.  
    January 4, 2014 | 8:43 AM
     

    Mickey,
    Thanks again. This led me to an interesting series from this Philosophy Journals.
    http://www.biomedcentral.com/content/pdf/1747-5341-7-3.pdf
    http://www.biomedcentral.com/content/pdf/1747-5341-7-8.pdf

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