I know I sometimes get kind of hung up on numbers, and it just happened. I was looking at Wagner et al in the last post because it was ghost-written, but I did read the abstract and something stuck with me. It’s highlighted in red below, "[effect size=2.9]". The effect size is a measure of […]
After the last post [a betrayal…], Psycritic commented that Celexa® had also been approved for adolescent depression by the FDA [I had said "Only Prozac®"]. I had a vague memory that something had happened, but was confused, so I took a look in Drugs @ FDA and got more confused. Then I tried Google and […]
Prozac Is No Magic Pill, but It Works New York Times by Robert Gibbons and J. John Mann October 7, 2014 The changes in treatment and attitude brought on by Prozac prompted two colliding points of view. One was that antidepressants were overprescribed and people were encouraged to turn to a pill to solve all their […]
In my medical lifetime, I’ve watched medicine turned into a business enterprise. I was fortunate to be able to hide in the cracks and mostly evade that myself – haunting places like training programs, academia, military service, a solo practice off the grid, a charity clinic. It’s not that I’m averse to systems. I’m just […]
from ChopstiX restaurantRaleigh NC
The order of things: the prequel… unanswered questions… the sequels Whether you think the introduction of the DSM-III in 1980 was a necessary specialty-saving intervention, a hostile take-over, a revolution, a bloodless coup d’état, right or wrong, isn’t what this post is about. It’s about the long term ramifications of a professional organization itself orchestrating […]
Tom Jefferson is a researcher/reviewer with the Cochrane Collaboration. He was involved throughout in the Tamiflu story and the Cochrane meta-analysis of the Tamiflu Trials. He’s as good a resource as we might find for understanding what the EMA’s recent policy decision really says: EMA’s release of regulatory data — trust but verify British Medical […]
I wrote this before the last post. Even as I wrote it, I knew I was writing it to myself, mainly to get things straight in my own thinking. But I changed my mind about posting it for two reasons. First, many of you aren’t psychiatrists and may not know the chronology so intimately – […]
In my home town, there was a 19th century bridge across the Tennessee River. It was designed with bolts that were intended to be tightened and loosened with the seasons, but that never happened. Over a 90 year period, the subtle stresses and strains of seasonal expansion and contraction rendered it unsafe for auto traffic […]
A response to: Uncovering the Hidden Risk Architecture of the Schizophrenias: Confirmation in Three Independent Genome-Wide Association Studies by Javier Arnedo, M.S. Dragan M. Svrakic, M.D., Ph.D. Coral del Val, Ph.D. Rocío Romero-Zaliz, Ph.D. Helena Hernández-Cuervo, M.D. Molecular Genetics of Schizophrenia Consortium Ayman H. Fanous, M.D. Michele T. Pato, M.D. Carlos N. Pato, M.D., Ph.D. […]