A 2002 article by Stanford Biostatistician Helena Chmura Kraemer et al summarizes the "characteristics of a well-performed RCT" [referencing the 1986 classic, Clinical Trials: Design, Conduct, and Analysis, by Curtis Meinert]: Considerable progress has been made in the development and evaluation of treatments, both pharmacologic and psychological, for a variety of different psychiatric disorders. This […]
I was hoping to move away from the Study 329 paper for a while, mainly not to run the boring in 1boringoldman into the ground, but something came up today that I thought was in need of emphasizing. During the 2 years writing the paper, there were a number of subplots along the way. As […]
I know I’m a broken record with this 329 stuff. ‘Blog’ came from parsing ‘Weblog’ into ‘We Blog’ – and when push comes to shove, all you can write about is what’s in your mind. This is what’s in there right now [still]… In study 329 ix – mystic statistics… I was talking about the […]
[The following emails from the American Academy of Child and Adolescent Psychiatry and the Journal of the American Academy of Child and Adolescent Psychiatry were forwarded to me by members] 09/16/2015 Dear Members, This week, The BMJ published a study, “Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression […]
re·al·ize /rëà,liz/ verb become fully aware of [something] as a fact; understand clearly [I’ve preferred to think of to re·al·ize as "to make real"] I had no conscious intention of parsing the verbs to ra·tion·al·ize and to re·al·ize in back to back posts. I wrote the last post, then read today’s installment of America’s Most […]
ra·tion·al·ize /raSHne,liz/ verb attempt to explain or justify [one’s own or another’s behavior or attitude] with logical, plausible reasons, even if these are not true or appropriate [I’ve preferred to think of to ra·tion·al·ize as "to start with a conclusion"] Confluence, Not Conflict of InterestName Change Necessary JAMA by Anne R. Cappola and Garret A. […]
I’m not old enough to have been around during the days of Bromides [Nervine], or Barbiturates, or Meprobamate [Miltown], or Methaqualone [Quaalude]. I grew up in the age of Benzodiazepine [Librium, Valium, Klonopin, Xanax]. We all know what they do so we don’t have to have any clinical trials. We all know they’re effective short […]
Why America’s Top Mental Health Researcher Joined Alphabet Tom Insel explains why he’s ready to give Silicon Valley a try. MIT Technology Review By Antonio Regalado September 21, 2015 We are at a really interesting moment in time. Technology that already has had such a big impact, on entertainment and so many aspects of our […]
Just a quick note to say that if you’re reading this blog and you’re not reading Steven Brill’s America’s Most Admired Lawbreaker in the Huffington Post about Alex Gorsky, J&J, Risperidal, and related matters, you’re making a big mistake. Today was Day 7 of 15, and he’s getting to the good parts. It’s a story […]
One might think that with all of the supportive media coverage our Study 329 article has received, I would be able to shake off the response from lead author, Martin Keller, reproduced from Retraction Watch in the last post [keller responds…], or his comment in The Chronicle of Higher Education: Dr. Keller contacted The Chronicle […]