John Henry was an American Folk Hero. He was a steel driving man in the era when they laid the railroad lines by hand. In one version of the legend, when they introduced a steam-driven hammer to cut the tunnels, John Henry and the new-fangled machine were pitted against each other. John Henry won with […]
[continued from outcome switching…] My title is facetious – guilty as charged. What I’m pointing to is that there are more ways to bugger a Clinical Trial Protocol than changing the outcome variables after the study is underway like they did in Paxil Study 329. One way is to change the dataset definition [what comes […]
In our reanalysis of Paxil Study 329 [Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence], we challenged the fact that the published paper reached it’s conclusions about efficacy based on an analysis of outcome variables that were not included in the a priori protocol: There were […]
This figure is obviously adapted from the last post [oh well…]. It’s the strength of effect [Standardized Mean Difference AKA Cohen’s d AKA ~Hedges g] of the Atypical Antipsychotics [in black] in the treatment of Schizophrenia with the values for Brexpiperazole added below [in green]. The upper values are from thousands of patients compiled in […]
So there’s an article that I’ve looked up over and over. I referred to it a lot looking into Brexpiprazole. It compares the strength of effect of various parameters for the Atypical Antipsychotics. I thought it was a shame it wasn’t open access, so I went after its forest plots with my graphics program and […]