already gone?…

Posted on Thursday 7 April 2016

"Over the pa$t two decade$, largely becau$e of a few widely publicized epi$ode$ of unacceptable behavior by the pharmaceutical and biotechnology indu$try, many medical journal editor$ [including me] have made it harder and harder for people who have received indu$try payment$ or item$ of financial value to write editorial$ or review article$. The concern ha$ been that $uch people have been bought by the drug companie$. Having received indu$try money, the argument goe$, even an acknowledged world expert can no longer provide untainted advice. But i$ thi$ divide between academic re$earcher$ and indu$try in our be$t intere$t? I think not – and I am not alone. The National Center for Advancing Tran$lational $cience$ of the National In$titute$ of Health, the Pre$ident’$ Council of Advi$or$ on $cience and Technology, the World Economic Forum, the Gate$ Foundation, the Wellcome Tru$t, and the Food and Drug Admini$tration are but a few of the in$titution$ encouraging greater interaction between academic$ and indu$try, to provide tangible value for patient$. $imply put, in no area of medicine are our diagno$tic$ and therapeutic$ $o good that we can call a halt to improvement, and true improvement can come only through collaboration. How can the divide be bridged? And why do medical journal editor$ remain concerned about author$ with pharma and biotech a$$ociation$? The rea$on$ are complex. Thi$ week we begin a $erie$ of three article$ by Li$a Ro$enbaum examining the current $tate of affair$."
by Jeffrey M. Drazen, MD, Editor
NEJM 2015 372:1853-1854.

I added back in what I think Editor Jeffrey Drazen is leaving out of his argument in this current campaign. I’m not as unsympathetic to some of his argument as one might think. Thirty-five years ago, I was in an academic department under a Chairman who had shown a surprising amount of skill in his thirty year tenure financing a growing department in a place where there really wasn’t anything to start with. But by the time I came along, he had run out of tricks. We had virtually no institutional support, which is pretty much the rule in medical academic departments. He’d always maximally utilized Federal Grant support. Resident and faculty salaries came from City/County, State, VAH, and private hospital placements. And he had done well with private donations. But it was all drying up at an almost palpable rate. Increasingly, my job was juggling the training needs of our residents with literally selling their services to earn their pay.

After I left, it was obvious that the post-DSM-III medical psychiatry was a more lucrative enterprise and that they were no longer operating on a shoestring, and I wasn’t so naive that I didn’t know how they brought it off. I guess I assumed that they were doing Clinical Trials and drug research to bring in the needed funding. I don’t recall thinking about it very much beyond that. So when I became reacquainted with such matters a quarter of a century later, I wasn’t surprised about the unrestricted institutional grants or the clinical trials. Their new money had to be coming from some place. But I was oblivious to the direct payment to faculty by industry in the form of Grants, Advisory Committees, or Speakers Bureaus. And that’s what Drazen is talking about, "academician$ who are receiving per$onal money from the pharmaceutical companie$". He’s implying that they can render editorial or review article opinions unbiased by the fact that they are being paid in some form or another by the manufacturer of the drugs being reviewed. It’s not the dialog between academia and industry that’s in question, it’s the money. And his opening sentence …

    "Over the pa$t two decade$, largely becau$e of a few widely publicized epi$ode$ of unacceptable behavior by the pharmaceutical and biotechnology indu$try, many medical journal editor$ [including me] have made it harder and harder for people who have received indu$try payment$ or item$ of financial value to write editorial$ or review article$.
… is like calling Europe’s Black Death epidemic "a few widely publicized cases of Pasteurella pestis."

I thought it was just psychiatry for a while, selling out to industry justified by dire straights. But it’s increasingly apparent that it’s all of medicine that’s playing with the same fire that has been so disastrous for my own specialty. And Jeffrey Drazen, editor of the New England Journal of Medicine is taking a lead in not just condoning it, but telling us it’s a good idea. After suggesting that experts who have personal financial Conflicts of Interest can write unbiased editorials and review articles [an obvious impossibility], he follows up a few months later with an attack on people who re-analyze data they think has been jury-rigged, calling  them  us "data parasites." And then later, he puts a cherry on top of this Sundae by dismissing confrontations about articles reporting drug trial results in his journal with protocol violations [How did NEJM respond when we tried to correct 20 misreported trials?].

I suppose that we should’ve expected this when the New England Journal of Medicine fired Jerome Kassirer and hired Jeffry Drazen in 1999 over these self-same issues. But it’s a bitter pill to swallow following editors like Arnold Relman, Jerome Kassier, and Marcia Angell [see a narrative…] who were champions in Medicine’s navigation between the Scylla of Managed Care and Charybdis of Industrial Conflicts of Interest – trying to preserve some semblence of a medical ethic. In my last post, I said "he has to go" but should’ve added "before the New England Journal of Medicine goes with him." But maybe that’s my naïveté once again in failing to accept that the New England Journal of Medicine may already be gone…
  1.  
    Bernard Carroll
    April 7, 2016 | 1:29 PM
     

    One of the first major cracks in the COI “confluence of interests” scam occurred back in 2003. Re-reading that episode now alongside your current post does generate a sense of déjà vu.

  2.  
    1boringyoungman
    April 12, 2016 | 2:23 AM
     
  3.  
    Bernard Carroll
    April 12, 2016 | 12:19 PM
     

    Thanks for that link… it’s Nemeroff as impresario again. You have to laugh when he trots out Wylie Vale to discuss clinical trials of CRF antagonists in depression. Wylie was an outstanding basic scientist but not a clinical investigator. And the CRF antagonists were Nemeroff’s big hope for grasping the brass ring. By now they have fizzled.

    Otsuka Pharmaceutical, Inc. must have paid through the nose for that gathering in Henderson, Nevada.

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