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Archive for May, 2016

one note samba…

( OPINION )

breezin’ along in the trades [1956]

( OPINION )

Shorty Rogers Quintet

nocturne for flute [1956]

( OPINION )

Bud Shank Quartet

neural circuits 1…

( OPINION )

Usually, when we think of circuits, we think about a roughly circular path that ends in the same place it started, then repeats – like an electrical circuit or Escher’s fantastic circuit. But when people are talking about neural circuits, they seem to be using the term more like it’s used in the phrase, circuit […]

why is that?…

( OPINION )

The Randomized Clinical Trial of a psychoactive drug follows a monotonous and simple course: a Protocol defines how the study is to be conducted and analyzed the protocol is submitted to the Institutional Review Board [IRB] on approval of the protocol, the trial is Registered on clinicaltrials.gov the Trial is conducted, double blinded the Results […]

the jewel in the crown…

( OPINION )

The citalopram CIT-MD-18 pediatric depression trial: Deconstruction of medical ghostwriting, data mischaracterisation and academic malfeasance by Jureidini, Jon, Amsterdam, Jay, McHenry, Leemon International Journal of Risk & Safety in Medicine. 2016 28[1]:33-43. OBJECTIVE:Deconstruction of a ghostwritten report of a randomized, double-blind, placebo-controlled efficacy and safety trial of citalopram in depressed children and adolescents conducted in […]

Jumping the Gun“…."> the Decade of “Jumping the Gun“….

( OPINION )

It may seem peculiar, but it makes sense to me. As a young guy in medicine, I was pulled in two directions – research into things we don’t yet know, and the application of things we do know. The former was where my mind naturally headed, but the latter was what gave me a sense […]

weary…

( OPINION )

Five years ago, I ran across an Australian company called Brain Resources. It appeared to be primarily a Brain Training enterprise, but they were into a lot of other things too. They were financing iSPOT, a clinical trial of personalized medicine trying to predict antidepressant drug choice based on Genetic and/or other testing. And they […]

some voices in the clouds…

( OPINION )

All this talk of the recent suicide statistics and what they might mean isn’t my native land. I’m more used to thinking about suicide and meaning[s] one case at a time. I recalled something from my earliest days as a resident. One of the first lectures we had was about the standard suicide statistics. You […]