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still…

( politics )

 

about my connectomes

( politics )

While I haven’t thought about it very much, I made a move from the hardest of medical sciences to the softest without any transition. The first time around was in a lab with scintillation counters printing data to punch cards to feed into Fortran programs that cranked out ANOVA with p values. And then I […]

in need of another British Invasion

( politics )

UK Agency Will Ask Regulators for Trial Data if Drug Makers Refuse Pharmalot: WSJ by Ed Silverman September 11, 2014 In yet another sign of frustration with drug makers that do not release clinical trial data, the U.K. agency that is responsible for recommending coverage of medicines will ask European regulators for data if companies […]

in praise of monotonous clinical trial reports…

( politics )

I’ve noticed that there’s a pattern in this blog [and in your responses]. I write a post, and something sticks in my mind, and I chase it in the next. That often goes on for a couple of iterations. It’s apparently how I think. Readers tend to comment the first time around, then run out […]

in praise of anonymous, contactable members of the public

( politics )

Ed Silverman reports here on the end of a long story that has appeared in fragments for several years. It’s about Agomelatine, a Melatonin like compound, and a review article published in the Lancet by Ian Hickie and Naomi Rodgers at the end of 2011. Here’s the Pharmalot post: Servier Breached Industry Codes by Not […]

meta meta meta meta meta meta meta…"> meta meta meta meta meta meta meta…

( politics )

Last time around [note to self…], I mentioned a Cochrane Review [also published in the Lancet] of head to head studies of the antidepressants. This same group also did a meta-analysis for each of the major antidepressants. This is the one they did for Zoloft® [Sertraline]: Sertraline versus other antidepressive agents for depression by Cipriani […]

note to self…

( politics )

My last post about Zoloft® and it’s approval [an echo that needs to keep reverberating…] got me thinking about a number of things. In the UPDATE, I finally found that Laura A. Plumlee et. al. v. Pfizer had been denied on a technicality for the second time just this week. I also found a Louisiana […]

an echo that needs to keep reverberating…

( politics )

Dr. Roy Poses of Healthcare Renewal often writes about a concept – the anechoic effect [see themes…]. We all know about it. Some big story comes along and there’s a big reaction, outrage around, but then interest peters out and it’s forgotten – worse, nothing is done about it. It happens all the time. And […]

along the road…

( politics )

Irving Kirsch published an article in 2008 [Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration] that concluded: Drug–placebo differences in antidepressant efficacy increase as a function of baseline severity, but are relatively small even for severely depressed patients. The relationship between initial severity and antidepressant efficacy is […]

that maturity…

( politics )

We shall not cease from exploration And the end of all our exploring Will be to arrive where we started And know the place for the first time… Little Gidding  T.S. Eliot 1942 I hate being so repetitive with my quotes. This one has had many re-runs here. But I guess that’s the way it […]