suspicious mind[s]…

Posted on Tuesday 21 February 2012

Yesterday, I got an email asking for the source of something I posted recently. It was from a pretty incriminating document from Forest Laboratories entitled Lexapro: FY04 Marketing Plan [available here]. I originally got the reference from one of Paul Thacker’s POGO articles [You’re Fired: Forest Lab’s CEO May Be Banned from Federal Healthcare]. The reason it’s so incriminating is obvious ["…developed by (or ghost-written for) thought leaders"]:

It was in a section called "Marketing Tactics" [stamped "Confidential"]. As I was looking it up, almost without thinking, I clicked through the section but woke up when I saw this:

Everything else in the section had an explanation for why it was there – everything but this. It was from a time when Dr. Nemeroff was Chairman at Emory. I didn’t know about any connection between Dr. Nemeroff with either Forest Laboratories or Lexapro, so I Googled <nemeroff+lexapro>. Up near the top was a link to something on the Lexapro web site – a page of suggested readings one of which was:

Here we go again. In 2004, Nemeroff was Chairman of Psychiatry at Emory and Editor-in-Chief, of Neuropsychopharmacology. That year, Dennis Charney was promoted to Dean at Mount Sinai Medical School. I actually kind of doubt they had much time to spend on a Self-Help Book. Monotonous isn’t it?

2001

So, who is Stephen R. Braun?  Well he’s written a couple of books:

19972001

Insert: And so friend Martha came by while I was nosing around and muttering about this. She went home and found Stephen R. Braun’s Webesite [braunmedicalmedia.com] describing his professional medical writing career, and it had this to say:

Note: No, Martha doesn’t ghost-write this blog, but she’s one fine Internet searcher.

But Dr. Nemeroff doesn’t include Stephen R. Braun as an author of The Peace of Mind Prescription in his résumé, just he and Dr. Charney. Based on the helpful rule of evidence often quoted by Dr. Phil ["the best predictor of future behavior is past behavior"], I’m hypothesizing that Steven R. Braun wrote this book [confirmed via Martha], and that Drs. Charney and Nemeroff were "guest authors," probably signed on by someone at Forest Laboratories, and that the $100,000 Institutional Grant listed at the top of the page is the payment. But how would one prove such an assertion? Stephen Braun doesn’t list Forest as a customer. Well, looking to see how Lexapro comes out in the book might be a start, so Mr. Amazon.com is kindly sending me a used copy for $0.08 + shipping as we speak. Why even bother? It’s because this kind of thing is how the chairmen KOLs built their departments with pharmaceutical institutional grants, and that’s why places like Emory University put up with these clowns. At least, that’s my hypothesis?

Later Addendum: Having awakened the beast, I received this email from Martha shortly after posting this:
    "Stephen Braun doesn’t list Forest as a customer"

    Ok, I’m into it now.  Here is Publishers Weekly review of his book The Science of Happiness: Unlocking the Mysteries of Mood:

    From Publishers Weekly:
    … Blasting "the drug company party line" that presents depression as a simple matter of out-of-balance brain chemicals, he sets forth cautionary case studies, meant to illustrate how dishonesty, manipulation and corporate greed can corrupt drug development, approval and marketing. (this is interesting!) Braun also takes exception to biological psychiatry’s view of depression as a solely neurochemically-based disease; he advocates a holistic approach to mental illness that recognizes that "talk therapy" is a vitally important component of the battle against depression. The most interesting part of the book is the nuanced epilogue, which details in diary-like fashion Braun’s own successful experience with a new drug, Celexa, after Prozac and Ritalin failed
Celexa and its refined version Lexapro are, of course, made by Forest Laboratories…
  1.  
    Peggi
    February 21, 2012 | 5:19 PM
     

    OMG. I wonder if Nemeroff ever had a working soul, or if he was born with a lost moral compass?

  2.  
    Ivan
    February 21, 2012 | 9:00 PM
     

    Anyone want to make book on what Charney and Nemeroff will claim? Some bs like we scrutinized the work product of Stephen Braun. LOL.

  3.  
    Bernard Carroll
    February 22, 2012 | 2:14 AM
     

    Don’t forget that Charney’s name graced the author list of the Cyberonics infomercial that brought down Nemeroff for nondisclosure of financial interests in 2006. Remember the Cyberonics debacle? The review that Sally Laden wrote?

    Charney and Nemeroff also cooked up the Emory-GlaxoSmithKline-NIMH Collaborative Mood Disorders Initiative (1U19MH069056). This project was supposed to do wonderful things for the pipeline of novel antidepressant drugs. The productivity of this multi-million dollar boondoggle can best be described as pitiful. And now that Nemeroff is out of Emory, the project management there has been inherited by Helen Mayberg, another of the Cyberonics co-authors. She is neither a psychiatrist nor a pharmacologist but a neurologist. As a former Emory faculty member, maybe NIMH Director Thomas Insel would like to explain that?

  4.  
    February 22, 2012 | 11:52 PM
     

    And then there was Charney’s editorial:

    Drs. Dwight Evans and Dennis Charney
    NIH funding since FY 2006: $30.6 million
    NIH funding FY 2010: $10,929,790
    According to the documents, Sally Laden of STI wrote an editorial for Biological Psychiatry in 2003 for Drs. Dwight Evans, Chairman of the Department of Psychiatry at the University of Pennsylvania School of Medicine, and Dennis Charney, then an employee at the NIH and now Dean of Research at the Mt. Sinai School of Medicine at New York University. In an email to a GSK employee, Ms. Laden wrote, “Is there a problem with my invoice for writing Dwight Evans’ editorial for the [Depression and Bipolar Support Alliance]’s comorbidity issue to Biological Psychiatry?” [Attachment B] Yet, when published, the “authors” Evans and Charney only stated, “We acknowledge Sally K. Laden for editorial support.”

    http://1boringoldman.com/index.php/2010/12/01/roaches/

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