Dr. Roy Poses of Healthcare Renewal often writes about a concept – the anechoic effect [see themes…]. We all know about it. Some big story comes along and there’s a big reaction, outrage around, but then interest peters out and it’s forgotten – worse, nothing is done about it. It happens all the time. And […]
Irving Kirsch published an article in 2008 [Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration] that concluded: Drug–placebo differences in antidepressant efficacy increase as a function of baseline severity, but are relatively small even for severely depressed patients. The relationship between initial severity and antidepressant efficacy is […]
We shall not cease from exploration And the end of all our exploring Will be to arrive where we started And know the place for the first time… Little Gidding T.S. Eliot 1942 I hate being so repetitive with my quotes. This one has had many re-runs here. But I guess that’s the way it […]
I wrote this less than four years ago [selling seroquel I: background…]: This email response to a researcher who was requesting funding from Zeneca several months after the F.D.A.’s approved Seroquel might seem odd or even Machiavellian to a Basic Scientist, a Practicing Clinician, or a patient-to-be, but if your business is selling the product, […]
This is an extension of the last post and its comments, specifically: "and this graph suggests that the patients essentially moved next door into our prisons" " If there is ever a place where the parable of the blind men and the elephant fits like a glove, this is it" "I begin to wonder about […]