Want to understand drug pricing? Tell pharma to open its books Pharmalot by Ed Silverman September 30, 2015 Like it or not, Martin Shkreli is the new face of pharma. And for an industry already struggling with an image problem over the rising costs of prescription drugs, companies are going to have a hard time distancing […]
A 2002 article by Stanford Biostatistician Helena Chmura Kraemer et al summarizes the "characteristics of a well-performed RCT" [referencing the 1986 classic, Clinical Trials: Design, Conduct, and Analysis, by Curtis Meinert]: Considerable progress has been made in the development and evaluation of treatments, both pharmacologic and psychological, for a variety of different psychiatric disorders. This […]
I was hoping to move away from the Study 329 paper for a while, mainly not to run the boring in 1boringoldman into the ground, but something came up today that I thought was in need of emphasizing. During the 2 years writing the paper, there were a number of subplots along the way. As […]
I know I’m a broken record with this 329 stuff. ‘Blog’ came from parsing ‘Weblog’ into ‘We Blog’ – and when push comes to shove, all you can write about is what’s in your mind. This is what’s in there right now [still]… In study 329 ix – mystic statistics… I was talking about the […]
[The following emails from the American Academy of Child and Adolescent Psychiatry and the Journal of the American Academy of Child and Adolescent Psychiatry were forwarded to me by members] 09/16/2015 Dear Members, This week, The BMJ published a study, “Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression […]
re·al·ize /rëà,liz/ verb become fully aware of [something] as a fact; understand clearly [I’ve preferred to think of to re·al·ize as "to make real"] I had no conscious intention of parsing the verbs to ra·tion·al·ize and to re·al·ize in back to back posts. I wrote the last post, then read today’s installment of America’s Most […]
ra·tion·al·ize /raSHne,liz/ verb attempt to explain or justify [one’s own or another’s behavior or attitude] with logical, plausible reasons, even if these are not true or appropriate [I’ve preferred to think of to ra·tion·al·ize as "to start with a conclusion"] Confluence, Not Conflict of InterestName Change Necessary JAMA by Anne R. Cappola and Garret A. […]
I’m not old enough to have been around during the days of Bromides [Nervine], or Barbiturates, or Meprobamate [Miltown], or Methaqualone [Quaalude]. I grew up in the age of Benzodiazepine [Librium, Valium, Klonopin, Xanax]. We all know what they do so we don’t have to have any clinical trials. We all know they’re effective short […]
Why America’s Top Mental Health Researcher Joined Alphabet Tom Insel explains why he’s ready to give Silicon Valley a try. MIT Technology Review By Antonio Regalado September 21, 2015 We are at a really interesting moment in time. Technology that already has had such a big impact, on entertainment and so many aspects of our […]
Just a quick note to say that if you’re reading this blog and you’re not reading Steven Brill’s America’s Most Admired Lawbreaker in the Huffington Post about Alex Gorsky, J&J, Risperidal, and related matters, you’re making a big mistake. Today was Day 7 of 15, and he’s getting to the good parts. It’s a story […]