At first, it seems an odd candidate as a symbol for problems with the current clinical trial culture. It’s a trial at an academic center rather than one run at some commercial clinical trial center. The Principle Investigator is the Chairman of Psychiatry at Columbia, the P.I. of the widely quoted NIMH C.A.T.I.E. trial, and […]
Flash: see the press release from the Nordic Cochrane center et al: Backpedalling on EMA’s “proactive publication of clinical-data” draft policy… Well, today is International Clinical Trials Day once again – celebrated from all sides of the controversies.The AllTrials campaign has a new video about Data Transparency: … while Clinical Research Organizations have many things […]
Howard Brody has an interesting post based on his junk mail: Are KOLs drying up? Praise be Hooked by Howard Brody May 14, 2014 Back in 2011 I heard from Cutting Edge Information on the subject of key opinion leaders [KOLs]: http://brodyhooked.blogspot.com/2011/06/keeping-kols-fat-and-sassy-these.html I figured that once I outed them on this blog, they would know […]
It’s a bit hard understanding quickly why this complaint is a big deal. Originally, the EMA proposed to simply release the raw data from Clinical Trials to qualified requesting parties. AbbVie and InterMune sued and held things up for a time, but AbbVie dropped their suit and things seemed to be on track. Now this. […]
How Being a Doctor Became the Most Miserable Profession The Daily Beast April 14, 2014 A former student of mine, a cardiologist, was seeing me on a consultation because of an abnormality in a test. The question was, "Did I need a cardiac catheterization?" I knew I didn’t. I expect the referring doctor knew I […]
So what’s a nice guy like me doing in a place like this? PhRMA.org? Google got me there when I was looking up something with Insel’s name in the search. But this is what greeted me: What needs to happen to ensure that ‘treatment’ is front and center in america’s ongoing conversation on mental illness […]
I realize that nosing around the NIMH RAISE Project is a little different than many of the things I write about here. Usually, I’m rooting around looking for corruption peeking out from behind the spin. But here, I’m looking for something else. I want these early psychosis programs to work. A career of seeing what […]
meaning … The Blockbuster Drug Comes to an End Forbes by Matthew Herper 04/06/2011 Geraldine Ferraro died from the rare blood cancer multiple myeloma on Mar. 26 after an 11-year battle. Breakthrough medicines kept the former congresswoman alive, but by 2007 she was worrying about their cost. The medicine she was taking at the end […]
How evidence-based medicine is failing due to biased trials and selective publication by Susanna Every-Palmer and Jeremy Howick Journal of Evaluation in Clinical Practice. 2014 May 12. [Epub ahead of print] [full text on-line] Evidence-based medicine [EBM] was announced in the early 1990s as a ‘new paradigm’ for improving patient care. Yet there is currently […]
Director’s Blog: From Research to Practice N.I.M.H. By Thomas Insel and Pamela Hyde, SAMHSA Administrator May 1, 2014 Conventional wisdom says that there is a long delay between a research finding and putting that finding into practice. Based on treatments for hypertension, that delay is usually described as 17 years. So it is especially worth […]