{"id":11193,"date":"2011-07-07T23:10:59","date_gmt":"2011-07-08T03:10:59","guid":{"rendered":"http:\/\/1boringoldman.com\/?p=11193"},"modified":"2011-07-08T05:11:03","modified_gmt":"2011-07-08T09:11:03","slug":"rotten-stuff","status":"publish","type":"post","link":"https:\/\/1boringoldman.com\/index.php\/2011\/07\/07\/rotten-stuff\/","title":{"rendered":"rotten stuff…"},"content":{"rendered":"\n

I know I’m bouncing around a lot, but it’s all a reaction to Harvard finally acting on their investigation of Dr. Joseph Biederman<\/font><\/strong> [bipolar kids: harvard acts…<\/font><\/a><\/strong>] which, in turn, brought up the bipolar child story. So for the last several weeks, I’ve been preoccupied with Dr. Biederman’s pet topic – bipolar disorder in children. It’s a little hard to get far enough away from his personal arrogant style to look carefully at his science. But, I must say that the science is so suffused with his pharmaceutical connections that he doesn’t make it easy. None-the-less, I think that while I’ll spot him that bipolar illness may be more common in kids than previously thought, I don’t buy his revision of the diagnostic criteria or his inclusion of large number of difficult kids in the category of ‘bipolar.’ He sure didn’t make his case with me. I was suspicious that he and his group were creating an illness to medicate, rather that looking for a treatment for an illness. <\/p>\n

But in looking over the child bipolar literature, I kept running across  other names that were familiar from Grassley’s investigations. Dr. Martin Keller<\/font><\/strong> from Brown was the PI on a big NIMH study of bipolar kids [COBY]. I knew of him from the infamous ghost-written Study 329 that made claims of efficacy and safety for Paxil, claims that just didn’t wash. Then I stumbled onto another Grassley alumni, Dr. Melissa Delbello<\/font><\/strong>, a child psychiatrist in Cincinnati who was also on the bipolar child bandwagon with lots of unreported industry income who was studying treating bipolar kids with Seroquel. When I looked at her work, they mentioned some bipolar child guidelines, and there I found Dr. Karen Wagner<\/font><\/strong> from UT Galveston. She was an author of the bipolar guidelines, she was a co-author with Keller on the Study 329 paper, and she was involved with the also infamous TMAP<\/font><\/strong> program in Texas, another topic of note. <\/p>\n

Maybe everyone else in America had already noticed that 6 of the 11 were child psychiatrists and 5 of the 6 child<\/font><\/strong> psychiatrists were studying bipolar<\/font><\/strong> children – but I hadn’t realized that.  <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n <\/tr>\n\n <\/tr>\n\n <\/tr>\n\n <\/tr>\n<\/table>\n

Senator Charles Grassley and Investigator Paul Thacker were targeting academic psychiatrists with pharmaceutical connections and unreported PHARMA income, not people in any particular research area. So the fact that his list contained a who’s who<\/strong> of childhood bipolar research makes a big statement all by itself about where PHARMA was focusing its efforts [and who was willing to take their money].<\/p>\n

I’m intrigued that there are two top TMAP<\/font><\/strong> algorithm types on the list [John Rush<\/font><\/strong> and Karen Wagner<\/font><\/strong>] and that one of them was involved in the bipolar kid’s algorithm project as well [Karen Wagner<\/font><\/strong>]. The whole idea of algorithms seems PHARMA-driven to me – ‘expert’ guidelines with paid experts. This is rotten stuff…<\/div>\n
\n
Update: Table tweaked with a little help from the comments… <\/div>\n","protected":false},"excerpt":{"rendered":"

I know I’m bouncing around a lot, but it’s all a reaction to Harvard finally acting on their investigation of Dr. Joseph Biederman [bipolar kids: harvard acts…] which, in turn, brought up the bipolar child story. So for the last several weeks, I’ve been preoccupied with Dr. Biederman’s pet topic – bipolar disorder in children. […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-11193","post","type-post","status-publish","format-standard","hentry","category-politics"],"_links":{"self":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/11193","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/comments?post=11193"}],"version-history":[{"count":19,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/11193\/revisions"}],"predecessor-version":[{"id":11213,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/11193\/revisions\/11213"}],"wp:attachment":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/media?parent=11193"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/categories?post=11193"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/tags?post=11193"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

Grassley’s Alumni<\/font><\/strong><\/td>\n<\/tr>\n
doctor<\/sup><\/font><\/strong><\/td>\nuniversity<\/strong><\/font><\/sup> <\/td>\nspecialty<\/sup><\/font><\/strong><\/td>\nresearch<\/sup><\/font><\/strong><\/td>\n<\/tr>\n
\n
<\/td>\n<\/tr>\n
Charles Nemeroff<\/sup><\/font><\/strong><\/td>\nEmory\/Miami<\/sup><\/td>\nadult<\/sup><\/td>\ndepression<\/sup><\/td>\n<\/tr>\n
Alan Schatzberd<\/sup><\/font><\/strong><\/td>\nStanford<\/sup><\/td>\nadult<\/sup><\/td>\ndepression<\/sup><\/td>\n<\/tr>\n
Joseph Biederman<\/sup><\/font><\/strong><\/td>\nHarvard<\/sup><\/td>\nchild<\/sup><\/font><\/strong><\/td>\nADHD, bipolar child<\/font><\/strong><\/sup> <\/td>\n<\/tr>\n
Timothy Wilens<\/sup><\/font><\/strong><\/td>\nHarvard<\/sup><\/td>\nchild<\/sup><\/font><\/strong><\/td>\nADHD, bipolar child<\/font><\/strong>
<\/sup><\/td>\n<\/tr>\n
Thomas Spencer<\/sup><\/font><\/strong><\/td>\nHarvard<\/sup><\/td>\nchild<\/sup><\/font><\/strong><\/td>\nADHD<\/sup> <\/td>\n<\/tr>\n
Jeffrey Bostic<\/sup><\/font><\/strong><\/td>\nHarvard<\/sup><\/td>\nchild<\/sup><\/font><\/strong><\/td>\ndepression<\/sup> <\/td>\n<\/tr>\n
Martin Keller<\/sup><\/font><\/strong><\/td>\nBrown<\/sup><\/td>\nadult<\/td>\ndepression, bipolar child<\/font><\/strong>
<\/sup><\/td>\n<\/tr>\n
John Rush<\/sup><\/font><\/strong><\/td>\nUT Dallas\/Duke
<\/sup><\/td>\n		adult<\/sup><\/td>\ndepression<\/sup><\/td>\n<\/tr>\n
Karen Wagner<\/sup><\/font><\/strong><\/td>\nUT Galveston
<\/sup><\/td>\n		child<\/sup><\/font><\/strong><\/td>\ndepression, bipolar child<\/font><\/strong>
<\/sup><\/td>\n<\/tr>\n
Melissa Delbello<\/sup><\/font><\/strong><\/td>\nCincinnati<\/sup><\/td>\nchild<\/sup><\/font><\/strong><\/td>\nbipolar child<\/sup><\/font><\/strong><\/td>\n<\/tr>\n
Fredrick Goodwin<\/sup><\/font><\/strong><\/td>\nNIMH\/NPR<\/sup><\/td>\nadult<\/sup><\/td>\nbipolar adults<\/sup><\/font><\/strong><\/td>\n<\/tr>\n