{"id":20020,"date":"2012-02-22T12:09:13","date_gmt":"2012-02-22T17:09:13","guid":{"rendered":"http:\/\/1boringoldman.com\/?p=20020"},"modified":"2012-02-22T12:22:13","modified_gmt":"2012-02-22T17:22:13","slug":"significant-i","status":"publish","type":"post","link":"https:\/\/1boringoldman.com\/index.php\/2012\/02\/22\/significant-i\/","title":{"rendered":"significant<\/em> I…"},"content":{"rendered":"\n

There has been no recent issue as hotly contested as the question of whether the SSRIs can induce suicidal thinking, particularly in youth. In 2004, the FDA added a black-box warning to the SSRIs, resulting in a fall in prescribing, and a polarized literature on this topic that lives on. Recently, the focus has been on the Treatment for Adolescents with Depression Study [TADS], first published in 2004. I walked in on an email discussion of several recent articles and found myself kind of confused. So first, I thought I’d gather the relevant links for anyone who might want to read along [most articles available on-line]: <\/p>\n

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A. There’s a full bibliography from TADS on the ClinicalTrials.gov site [first reference]. These articles are the ones I thought were relevant to the discussion of suicidality: <\/div>\n
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  1. \n
    <\/a>Treatment for Adolescents With Depression Study (TADS)<\/font><\/strong><\/u><\/a>
    NCT00006286 on ClinicalTrials.gov<\/font><\/strong><\/div>\n<\/li>\n
  2. \n
  3. \n
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  5. \n
    Suicidal Events in the Treatment for Adolescents with Depression Study (TADS)<\/font><\/strong><\/u><\/a>
    by Benedetto Vitiello, Susan Silva, Paul Rohde, Christopher Kratochvil, et al.<\/sup>
    Journal of Clinical Psychiatry<\/font><\/strong>. 2009 70(5): 741–747. [    full text on-line<\/font><\/strong><\/u><\/a>]<\/div>\n<\/li>\n<\/ol>\n
    B. There was a recent article by Gibbons reanalyzing TADS that reached some contended conclusions. My two response blogs have links to Gibbons’ previous articles, other takes on the question of SSRI suicidality, and various opinions about the effect of the 2004 black box warning: <\/div>\n
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    1. \n
    2. \n
    3. \n
      sometimes… <\/font><\/a><\/strong><\/u><\/div>\n<\/li>\n<\/ol>\n
      C. Recent commentary from David Healy and Robert Whitaker about TADS and Gibbons’ article: <\/div>\n
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      1. \n
      2. \n
        The Real Suicide Data from the TADS Study Comes to Light<\/font><\/strong><\/u><\/a>
        by Robert Whitaker<\/sup>
        February 20, 2012 <\/div>\n<\/li>\n<\/ol>\n
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        All of this post’s discussion hinges on the reference A.5. above, the Vitiello et al article that has this conclusion in the abstract:<\/div>\n