{"id":28183,"date":"2012-10-01T11:48:32","date_gmt":"2012-10-01T15:48:32","guid":{"rendered":"http:\/\/1boringoldman.com\/?p=28183"},"modified":"2012-10-01T21:15:21","modified_gmt":"2012-10-02T01:15:21","slug":"from-the-land-of-monty-python","status":"publish","type":"post","link":"https:\/\/1boringoldman.com\/index.php\/2012\/10\/01\/from-the-land-of-monty-python\/","title":{"rendered":"from the land of Monty Python&#8230;"},"content":{"rendered":"<div align=\"justify\">Back in the Spring, I was writing about the flurry of activity when the news of PHARMA&#8217;s exodus from CNS drug development hit, and I ran across a speech by British Neuropsychopharmacologist, Dr. David Nutt, at the Royal College of Psychiatry in June 2011 that antedated the more recent flurry of lamentations [<a href=\"http:\/\/www.rcpsych.ac.uk\/pdf\/Nutt%20KN16.pdf\" target=\"_blank\"><u><strong><font color=\"#200020\">No Psychiatry Without Psychopharmacology<\/font><\/strong><\/u><\/a>]. Following up on Dr. Nutt, I found this [<strong><a target=\"_blank\" href=\"http:\/\/1boringoldman.com\/index.php\/2012\/04\/25\/suddenly-last-summer\/\"><em><u><font color=\"#200020\">suddenly, last summer&hellip;<\/font><\/u><\/em><\/a><\/strong>]:<\/div>\n<blockquote>\n<div align=\"justify\"><em>There is an irony in this story. Dr. Nutt himself was a truth-sayer. In 2008, he became Chairman of the&nbsp; <u><strong><a title=\"Advisory Council on the Misuse of Drugs\" href=\"http:\/\/en.wikipedia.org\/wiki\/Advisory_Council_on_the_Misuse_of_Drugs\" target=\"_blank\"><font color=\"#200020\">Advisory Council on the Misuse of Drugs<\/font><\/a><\/strong><\/u>. He was an outspoken advocate for basing the laws about street drugs on their true <\/em><em>evidence-based dangers &ndash; publishing this graph in <strong>The Lancet<\/strong>:<\/em><\/div>\n<p align=\"center\"><a target=\"_blank\" href=\"http:\/\/en.wikipedia.org\/wiki\/File:Rational_scale_to_assess_the_harm_of_drugs_%28mean_physical_harm_and_mean_dependence%29.svg\"><img decoding=\"async\" width=\"300\" border=\"0\" src=\"http:\/\/1boringoldman.com\/images\/nutt-2.gif\" \/><\/a><br \/>              <sup>[click image for the link]<\/sup><\/p>\n<div align=\"justify\"><em>In 2009, Dr. Nutt was <\/em><a target=\"_blank\" href=\"http:\/\/www.bbc.co.uk\/blogs\/thereporters\/markeaston\/2009\/10\/nutt_gets_the_sack.html\"><u><strong><font color=\"#200020\">fired<\/font><\/strong><\/u><\/a><em> from this appointment because of his own <\/em><em>truth-saying  about Street Drugs [and one has to wonder where the prescription  medications Nutt both promotes and defends would fall on his own graph].<\/em><\/div>\n<\/blockquote>\n<div align=\"justify\"><sup>That last bit of sarcasm came because at the time I was writing the above, I was becoming acutely aware of how difficult and intractable the withdrawal syndromes from <\/sup><sup> some of the modern psychotherapeutic agents could be.<\/sup><\/div>\n<p align=\"justify\"><img decoding=\"async\" width=\"100\" vspace=\"2\" hspace=\"4\" border=\"1\" align=\"left\" src=\"http:\/\/www.viennadeclaration.com\/wordpress\/wp-content\/uploads\/2010\/10\/Writing-Committee-David-Nutt-Post-Thumb-150x150.jpg\" \/>I&#8217;m sure I&#8217;m not the first person to wonder about the relationship between the sixties&#8217; drug culture and the later preoccupation of psychiatry with psychopharmacology, so I found Nutt&#8217;s position interesting. He is a past president of the British Association of Psychopharmacology and of the European College of Neuropsychopharmacology. He is the president of the British Neuroscience Association and vice-president of the European Brain Council. Dr. Nutt hardly has the look and feel of a latter-day hippie.<\/p>\n<div align=\"justify\">That story occasionally occurs to me when I read about medical Marijuana or about the use of Ketamine in the treatment of depression &#8211; the interface between these drug cultures. But I wasn&#8217;t quite prepared for this &#8211; Dr. Nutt&#8217;s appearance on British television testing the drug Ecstasy [MDMA] in celebrity volunteers, complete with fMRI. One episode of a two part series has shown and the other is on soon. A few links:<\/div>\n<ul>\n<li>\n<div align=\"justify\"><a href=\"http:\/\/www.guardian.co.uk\/commentisfree\/2012\/sep\/21\/ecstasy-david-nutt-channel-4\" target=\"_blank\"><u><strong><font color=\"#200020\">David Nutt and Julia Manning: is it right to take ecstasy in a TV trial?<\/font><\/strong><\/u><\/a><\/div>\n<\/li>\n<li>\n<div align=\"justify\"><a href=\"http:\/\/www.telegraph.co.uk\/culture\/tvandradio\/9569797\/Drugs-Live-the-Ecstasy-Trial-Channel-4-review.html\" target=\"_blank\"><u><strong><font color=\"#200020\">Drugs Live: the Ecstasy Trial, Channel 4, review<\/font><\/strong><\/u><\/a><\/div>\n<\/li>\n<li>\n<div align=\"justify\"><a href=\"http:\/\/gyngellblog.dailymail.co.uk\/2012\/09\/more-sophistry-than-science-and-terrible-telly-to-boot-thats-my-verdict-on-channel-fours-dire-drugs-.html\" target=\"_blank\"><u><strong><font color=\"#200020\">More sophistry than science &ndash; and terrible telly to boot<\/font><\/strong><\/u><\/a><\/div>\n<\/li>\n<li>\n<div align=\"justify\"><a href=\"http:\/\/www.mixmag.net\/words\/features\/professor-david-nutt-talks-drugs-live\" target=\"_blank\"><u><strong><font color=\"#200020\">PROFESSOR DAVID NUTT TALKS DRUGS LIVE<\/font><\/strong><\/u><\/a><\/div>\n<\/li>\n<li>\n<div align=\"justify\"><a href=\"http:\/\/www.thesun.co.uk\/sol\/homepage\/features\/4557220\/keith-allen-takes-drugs-on-tv-in-drugs-live-the-ecstasy-trial.html\" target=\"_blank\"><u><strong><font color=\"#200020\">\t Does taking ecstasy live on telly glamorise drugs?<\/font><\/strong><\/u><\/a><\/div>\n<\/li>\n<li>\n<div align=\"justify\"><a href=\"http:\/\/www.huffingtonpost.co.uk\/dr-john-turner\/mdma-drugs-live_b_1916335.html?utm_hp_ref=uk\" target=\"_blank\"><u><strong><font color=\"#200020\">\t MDMA and C4&#8217;s &#8216;Drugs Live&#8217;<\/font><\/strong><\/u><\/a><br \/>   <sup>One final point that I feel also needs a brief mention is that this programme may also reinforce some other potentially unhealthy behaviours, notably amongst scientists and psychiatrists [who are generally not the same creature]. The treatment of serious mental health problems has a very dark history, which has seen the reduction of distress to the language of receptors and neurotransmitters, and the portrayal of pharmacology as the way forward. In recent years the poverty of direct evidence for neurochemical imbalances in the brains of people with mental ill-health diagnoses, and of the relative weaknesses of the chemical cure [especially for schizophrenia and depression] have shown the flaws in the standard psychiatric\/medical model of managing such problems.  These trials with MDMA, though interesting, are also worrying from this perspective too; in part continuing this drug-focussed tradition, obsession perhaps, of those charged with helping us navigate madness.<\/sup><\/div>\n<\/li>\n<\/ul>\n<div align=\"justify\">I pass it on because it&#8217;s there. The pipeline might really be that empty&#8230;<\/div>\n<hr size=\"1\" \/>\n<div><strong><font color=\"#200020\">UPDATE<\/font><\/strong>: And the beat goes on. Is he <em>onto<\/em> something? or <em>on<\/em> something?<\/div>\n<blockquote>\n<div align=\"center\"><a href=\"http:\/\/www.fiercebiotech.com\/story\/magic-mushroom-depression-therapy-prepped-controversial-clinical-trial\/2012-10-01\" target=\"_blank\"><u><strong><font color=\"#200020\">Magic mushroom depression therapy prepped for controversial clinical trial<\/font><\/strong><\/u><\/a><br \/><strong><font color=\"#200020\">FiercePharma<\/font><\/strong><br \/> By John Carroll<br \/>October 1, 2012<\/div>\n<p><\/p>\n<div align=\"justify\"><sup>David Nutt, a prominent and often controversial investigator at  Imperial College London, has landed about $800,000 from the U.K.&#8217;s  Medical Research Foundation to test the active ingredient in &quot;magic  mushrooms&quot; as a possible new treatment for depression. Working with the knowledge that psilocybin  has been linked to long-term relief for cases of serious depression,  Nutt has lined up a manufacturer able to produce a dose that can be  injected in about 30 patients. Investigators will take brain scans of  the volunteers to help determine how the therapy works.<\/p>\n<p>   Three years ago,&nbsp;Nutt was bounced out of his role as chairman of the  U.K. government&#8217;s advisory council on drugs after making some  controversial remarks on the relative dangers of ecstasy. And it hasn&#8217;t  been easy getting to this stage of his work on psilocybin, relying  heavily on help from supporters. Even if the drugs works in the trial,  there&#8217;s a major hurdle between his treatment and any kind of marketed  product: It&#8217;s an illegal substance. &quot;One of the things to change in parallel with the trial is the law,&quot; he told <em>The Financial Times<\/em>. &quot;Otherwise the big problem is if it works, no one will be able to prescribe it.&quot;<\/sup><\/div>\n<\/blockquote>\n<div align=\"center\"><img loading=\"lazy\" decoding=\"async\" width=\"254\" height=\"199\" border=\"1\" src=\"http:\/\/1boringoldman.com\/images\/nutt-4.jpg\" \/>&nbsp;<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Back in the Spring, I was writing about the flurry of activity when the news of PHARMA&#8217;s exodus from CNS drug development hit, and I ran across a speech by British Neuropsychopharmacologist, Dr. David Nutt, at the Royal College of Psychiatry in June 2011 that antedated the more recent flurry of lamentations [No Psychiatry Without [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-28183","post","type-post","status-publish","format-standard","hentry","category-politics"],"_links":{"self":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/28183","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/comments?post=28183"}],"version-history":[{"count":32,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/28183\/revisions"}],"predecessor-version":[{"id":28261,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/28183\/revisions\/28261"}],"wp:attachment":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/media?parent=28183"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/categories?post=28183"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/tags?post=28183"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}