{"id":28494,"date":"2012-10-07T17:27:44","date_gmt":"2012-10-07T21:27:44","guid":{"rendered":"http:\/\/1boringoldman.com\/?p=28494"},"modified":"2012-10-07T19:21:56","modified_gmt":"2012-10-07T23:21:56","slug":"the-letter-and-spirit-of-the-law-a-time-for-a-new-precedent","status":"publish","type":"post","link":"https:\/\/1boringoldman.com\/index.php\/2012\/10\/07\/the-letter-and-spirit-of-the-law-a-time-for-a-new-precedent\/","title":{"rendered":"the letter and spirit of the law: a time for a new precedent&#8230;"},"content":{"rendered":"<br \/>\n<blockquote>\n<div align=\"center\"><a target=\"_blank\" href=\"http:\/\/www.nytimes.com\/2012\/10\/06\/opinion\/fraud-in-the-scientific-literature.html?partner=rssnyt&#038;emc=rss\"><u><strong><font color=\"#200020\">Fraud in the Scientific Literature<\/font><\/strong><\/u><\/a><br \/>                       <strong><font color=\"#200020\">New York Times<\/font><\/strong><br \/>                       Editorial<br \/>                       October 5, 2012<\/div>\n<p>                      <\/p>\n<div align=\"justify\"><sup><strong>A surprising upsurge  in the number of scientific papers that have had to be retracted  because they were wrong or even fraudulent has journal editors and  ethicists wringing their hands. The retracted papers are a small  fraction of the vast flood of research published each year, but they  offer a revealing glimpse of the pressures driving many scientists to  improper conduct. Last year, Nature,  a leading scientific journal, calculated that published retractions had  increased tenfold over the past decade &mdash; to more than 300 a year &mdash; even  though the number of papers published rose only 44 percent. It  attributed half of the retractions to embarrassing mistakes and half to  &ldquo;scientific misconduct&rdquo; such as plagiarism, faked data and altered  images. <\/p>\n<p>                        Now a new study,  published in the Proceedings of the National Academy of Sciences, has  concluded that the degree of misconduct was even worse than previously  thought. The authors analyzed more than 2,000 retracted papers in the  biomedical and life sciences and found that misconduct was the reason  for three-quarters of the retractions for which they could determine the  cause. The problem is global. Retracted papers were written in more than 50  countries, with most of the fraud or suspected fraud occurring in the  United States, Germany, Japan and China. The problem may even be greater  than the new estimates suggest, the authors say, because many journals  don&rsquo;t explain why an article was retracted &mdash; a failure that calls out  for uniform guidelines.<\/p>\n<p>                        There are many theories for why retractions and fraud have increased. A  benign view suggests that because journals are now published online and  more accessible to a wider audience, it&rsquo;s easier for experts to spot  erroneous or fraudulent papers. A darker view suggests that  publish-or-perish pressures in the race to be first with a finding and  to place it in a prestigious journal has driven scientists to make  sloppy mistakes or even falsify data. The solutions are not obvious, but  clearly greater vigilance by reviewers and editors is needed.<\/strong><\/sup><\/div>\n<\/blockquote>\n<p align=\"center\">From the PNAS study [see <strong><a href=\"http:\/\/1boringoldman.com\/index.php\/2012\/10\/03\/what-he-said\/\" target=\"_blank\"><u><font color=\"#200020\">what he said&hellip;<\/font><\/u><\/a><\/strong>]:<\/p>\n<p align=\"center\"><img decoding=\"async\" width=\"396\" border=\"0\" src=\"http:\/\/1boringoldman.com\/images\/retraction.gif\" \/><br \/>                    <sup>[reformatted for clarity]<\/sup><\/p>\n<table width=\"95%\" cellspacing=\"0\" cellpadding=\"5\" border=\"0\" align=\"center\">\n<tr>\n<td>\n<div align=\"justify\">In the law, there are layers of justice. Did the defendant break the law beyond any shadow of doubt? Was the procedure that convicted the defendant proper, following the <font color=\"#200020\">letter of the law<\/font>? We even have a word for that:<\/div>\n<ul>\n<div align=\"justify\"><strong><font color=\"#200020\">le&middot;gal&middot;is&middot;tic<\/font><\/strong>&nbsp; <font color=\"#200020\"><span class=\"pron\">[l<img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/emacr.gif\" \/><img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/prime.gif\" \/>g<img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/schwa.gif\" \/>-l<\/span><span class=\"pron\"><img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/ibreve.gif\" \/>s<img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/prime.gif\" \/>t<img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/ibreve.gif\" \/>k]<\/span><\/font><br \/>           <font color=\"#200020\">&mdash; <em>adjective<\/em><\/font><\/div>\n<ol>\n<div align=\"justify\"><font color=\"#200020\">of, relating to, or exhibiting strict adherence to the law, especially to the letter of the law rather than its spirit.<\/font><\/div>\n<\/ol>\n<\/ul>\n<div align=\"justify\">The the accused gets all the breaks, whereas the authorities must follow their rigid procedures or the criminal walks. Two systems, one for the criminal and another for the policeman. This dichotomy is the subject of endless television series and movies &#8211; bad cops; good cops who bend the law in the service of Truth, Justice, and the American way; the other kind of bad cops. And while we all know the historical reasons for insisting on such pristine behavior from our criminal justice system, we still cheer weekly as Brenda Lee [the Closer] bends the rules to get the bad guys.<\/div>\n<\/td>\n<\/tr>\n<\/table>\n<p align=\"justify\">In certain areas, we hold people to a higher standard: elected and legal officials, airline pilots, doctors, scientists, even our lawyers. When accused, we come closer to a standard of &quot;guilty until declared innocent&quot; than the opposite from our criminal system &#8211; a standard of &quot;above suspicion.&quot;   <\/p>\n<p align=\"justify\">The point here is that the predictable reaction to that editorial or the graphs from the PNAS article is to be horrified that the scientists are <em>sinners<\/em>, and that <em>scientific sin<\/em> is on the rise. We don&#8217;t expect that. From my perspective as someone who has spent a lot of time looking at the scientific literature produced over the last twenty years in psychiatry, my reaction is different. I see that graph as the tip of an iceberg, and the <u>result<\/u> of allowing scientists the latitude afforded criminals instead of applying a time honored higher standard. In the case of the article often discussed here [Paxil Study 329], no one questions that it is not just wrong, but it is <u>wrong on purpose<\/u>. It was shepherded into the literature by an unethical pharmaceutical company using a talented ghost-writer and endorsed by scientists who were hardly moral giants. They didn&#8217;t change the data &#8211; instead they mis-used the tools of science to twist it beyond recognition to reach a conclusion that was the opposed to its true meaning [<u>on purpose<\/u>]. And we know that&#8217;s true because we have all the details, including a $3 B confession by the pharmaceutical cartel that masterminded the dirty deed.<\/p>\n<div align=\"justify\">So why hasn&#8217;t Paxil Study 329 been retracted? A medley of <strong><font color=\"#200020\">le&middot;gal&middot;is&middot;tic<\/font><\/strong> <font color=\"#200020\"><span class=\"pron\">[l<img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/emacr.gif\" \/><img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/prime.gif\" \/>g<img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/schwa.gif\" \/>-l<\/span><span class=\"pron\"><img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/ibreve.gif\" \/>s<img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/prime.gif\" \/>t<img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/ibreve.gif\" \/>k] <\/span><\/font>arguments [see <a href=\"http:\/\/simonwessely.com\/Downloads\/Publications\/Military\/Woodhead2011-rapeconflict.pdf\" target=\"_blank\"><u><strong><font color=\"#200020\">The Rules of Retraction<\/font><\/strong><\/u><\/a>]:<\/div>\n<ul><sup><strong>       <\/p>\n<li>\n<div align=\"justify\">they didn&#8217;t fabricate or falsify the data<\/div>\n<\/li>\n<li>\n<div align=\"justify\">&quot;no evidence of scientific errors&quot;<\/div>\n<\/li>\n<li>\n<div align=\"justify\">&quot;nor any justification for retraction according to current editorial standards and scientific publication guidelines&quot;<\/div>\n<\/li>\n<li>\n<div align=\"justify\">&quot;It  generated all sorts of useful discussion which is the purpose of a  scholarly journal&quot;<\/div>\n<\/li>\n<li>\n<div align=\"justify\">&quot;There are very many papers where, if you looked at the data, you could argue that the conclusions are not justified&quot;<\/div>\n<\/li>\n<li>\n<div align=\"justify\">&quot;Many highly expert child and adolescent psychiatrists were participants in that study, and others that were similar, and others equally expert contributed to the review process&quot;<\/div>\n<\/li>\n<p>      <\/strong><\/sup><\/ul>\n<div align=\"justify\">Melanie Newman&#8217;s 2010 article in the <strong><font color=\"#0033ff\">British Medical Journal<\/font><\/strong> [<a href=\"http:\/\/simonwessely.com\/Downloads\/Publications\/Military\/Woodhead2011-rapeconflict.pdf\" target=\"_blank\"><u><strong><font color=\"#200020\">The Rules of Retraction<\/font><\/strong><\/u><\/a>] tells the story prior to the recent GSK $3 B settlement in which they admit all allegations, including the dark story of Paxil Study 329. So now that <strong><font color=\"#200020\">legal settlement<\/font><\/strong> is in the mix. The Spirit of the Law in this case is not in question. All scientists know how it should be. None would argue that using the tools of science to misrepresent scientific data is fair game. It&#8217;s the Letter of the Law that&#8217;s on the line. <\/div>\n<div align=\"justify\"><strong>L<font color=\"#200020\">e&middot;gal&middot;is&middot;tic<\/font><\/strong> <font color=\"#200020\"><span class=\"pron\">[l<img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/emacr.gif\" \/><img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/prime.gif\" \/>g<img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/schwa.gif\" \/>-l<\/span><span class=\"pron\"><img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/ibreve.gif\" \/>s<img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/prime.gif\" \/>t<img decoding=\"async\" border=\"0\" align=\"absbottom\" src=\"http:\/\/img.tfd.com\/hm\/GIF\/ibreve.gif\" \/>k] <\/span><\/font>arguments rely on precedents [and sometimes on hypotheticals] and in this case, there really aren&#8217;t any solid precedents because these things don&#8217;t directly end up in courtrooms, at least not yet. There are just some guidelines scattered around with nothing like &quot;case law.&quot; But the ramifications do end up in court &#8211; like this recent settlement with GSK or the numerous Civil suits won in part on the evidence of the misbehavior in this particular article. And Study 329 is not alone in the psychiatric literature &#8211; only a well-known example of the conscious, willful, and deceitful use of scientific methodology by a commercial enterprise in concert with academic physicians to defraud help-seeking patients by giving their physicians false information without <strong><font color=\"#200020\">fabricating<\/font><\/strong> or <strong><font color=\"#200020\">falsifying<\/font><\/strong> the data. <\/div>\n<p align=\"justify\">So we need a precedent. We need for someone to step up to the plate and do the obviously right thing, retracting the article, ignoring the <strong><font color=\"#200020\">le&middot;gal&middot;is&middot;tic<\/font><\/strong> arguments as inappropriate for a respected scientific community. The only reason that Medicine is respected is that it is believed to operate on a higher ethic than the courts of crimes and misdemeanors. And who should move for retraction? The <strong><font color=\"#200020\">American Academy of Child and Adolescent Psychiatry<\/font><\/strong>. Paxil Study 329 was published by their official journal, and the vulnerable population they treat and represent were the inured party. It&#8217;s their precedent to set.  <\/p>\n<div align=\"justify\">The way to get that graph to look better is to stop overlooking this kind of fraud and assert the ethic that we hold so precious. The only way to get that graph to go down is to push it up to where it belongs&#8230;<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Fraud in the Scientific Literature New York Times Editorial October 5, 2012 A surprising upsurge in the number of scientific papers that have had to be retracted because they were wrong or even fraudulent has journal editors and ethicists wringing their hands. The retracted papers are a small fraction of the vast flood of research [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-28494","post","type-post","status-publish","format-standard","hentry","category-politics"],"_links":{"self":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/28494","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/comments?post=28494"}],"version-history":[{"count":52,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/28494\/revisions"}],"predecessor-version":[{"id":28546,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/28494\/revisions\/28546"}],"wp:attachment":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/media?parent=28494"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/categories?post=28494"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/tags?post=28494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}