{"id":34166,"date":"2013-03-13T16:42:01","date_gmt":"2013-03-13T20:42:01","guid":{"rendered":"http:\/\/1boringoldman.com\/?p=34166"},"modified":"2013-03-13T21:51:10","modified_gmt":"2013-03-14T01:51:10","slug":"sign-up","status":"publish","type":"post","link":"https:\/\/1boringoldman.com\/index.php\/2013\/03\/13\/sign-up\/","title":{"rendered":"sign up&#8230;"},"content":{"rendered":"<div align=\"justify\"><a href=\"https:\/\/www.change.org\/petitions\/governor-mark-dayton-of-minnesota-investigate-psychiatric-research-misconduct-at-the-university-of-minnesota-2\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" width=\"162\" hspace=\"4\" height=\"120\" border=\"0\" align=\"right\" src=\"http:\/\/1boringoldman.com\/images\/dan-m.gif\" alt=\"The Dan Markinson Petition\" title=\"The Dan Markinson Petition\" \/><\/a>If you don&#8217;t know about the <font color=\"#200020\">Dan Markingson<\/font> Case, it&#8217;s worth looking into. The icon on the left sidebar takes you to a petition to the Governor of Minnesota requesting an complete investigation. Carl Elliott has pressed for an investigation with little success and has now set up a petition to the Minnesota Governor asking for a full accounting. Take a look and sign it if this case looks as bad to you as it does to me [it will]. [Note: I had to use the Internet Explorer to sign it]. Here&#8217;s what I wrote when I first read about the case three years ago. The references mentioned in the Brody piece have the whole story:<\/div>\n<blockquote>\n<div align=\"justify\">This post is about a tragic and outrageous  story. It&rsquo;s about a young man who had a Schizophrenic Break after  college. He was involuntarily hospitalized after becoming homicidal. He  ended up voluntarily enrolling in a drug study comparing three atypical  antipsychotics [even though he had been declared legally incompetent].  His condition deteriorated, but the medicine remained unchanged. In  spite of desperate warnings to his doctors by his mother, he finally  committed suicide. There are few things more ominous than such a  psychotic episode in the life of a young adult. In spite of the toxicity  of the drugs used to treat this condition, it is something of a modern  miracle that such an illness can be treated. But it requires careful  monitoring, often changing drugs or dosage depending on the response. To  simply place a person on an arbitrary dose of a randomly assigned drug  would be unheard of in a rational clinical setting. And to enroll a  person as flagrantly psychotic and dangerous as this young man in such a  study is simply folly [any Psychiatry Resident could tell you that  after a month working on the wards]. Dr. Bernard Carroll, who alerted me  to this article, labels irresponsible studies like this one <a href=\"https:\/\/www.blogger.com\/comment.g?blogID=1732132352927731247&#038;postID=3430948839916994866\" target=\"_blank\"><strong><font color=\"#200020\">experimercials<\/font><\/strong><\/a>, to highlight the fact that <strong>they&rsquo;re not driven by a scientific quest, but rather by a marketing strategy.<br \/>    <\/strong><\/div>\n<ul>\n<div align=\"center\"><strong><a href=\"http:\/\/brodyhooked.blogspot.com\/2010\/08\/continuing-our-all-carl-elliott-issue.html\" target=\"_blank\">Continuing Our All-Carl-Elliott Issue: More on the Dan Markingson Case<\/a><br \/>      Hooked: Ethics, Medicine, and Pharma <\/strong><br \/>      by Howard Brody<br \/>      August 20, 2010<\/div>\n<p>  <\/p>\n<div align=\"justify\">Back in April I <a href=\"http:\/\/brodyhooked.blogspot.com\/2010\/04\/u-minnesota-evading-responsibility-for.html\" target=\"_blank\"><strong>blogged<\/strong><\/a>  about the tragic case of Dan Markingson and the so-far-futile efforts  of his mother, Mary Weiss, to get justice from the University of  Minnesota. Carl Elliott&rsquo;s book [<a target=\"_blank\" href=\"http:\/\/www.amazon.com\/White-Coat-Black-Hat-Adventures\/dp\/0807061425\"><strong><em>White Coat, Black Hat: Adventures on the Dark Side of Medicine<\/em><\/strong> <\/a>(Boston:  Beacon Press, 2010, ISBN 978-0-8070-6142-8)] contains a brief synopsis  of this case; but he goes into more detail in an article in the current <em>Mother Jones<\/em>, &quot;<strong>Making a Killing<\/strong>.&quot;<\/div>\n<\/ul>\n<\/blockquote>\n<div><strong><font color=\"#200020\">Note:<\/font><\/strong> &quot;<strong>Making a Killing<\/strong>&quot;is now available as a pdf file <a href=\"http:\/\/anewmerckreviewed.files.wordpress.com\/2010\/08\/sgp-seroquel-suicide-motherjones.pdf\" target=\"_blank\">here<\/a>&#8230;  <\/div>\n<blockquote>\n<ul>\n<div align=\"justify\">In &quot;<strong>Making a Killing<\/strong>,&quot; Carl not only  describes the sad case but also puts it in the context of the pressure  placed on universities today to compete for grant dollars with  commercial research entities, all funded by a drug industry that is  looking for marketing, not science. As Carl summarizes: <\/div>\n<ol>\n<div align=\"justify\"><strong><em>&quot;<\/em><font color=\"#200020\"><em>If  these experts [who have reviewed the study in which Dan Markingson was  enrolled, and have declared it to be scientifically next to worthless]  are right, then then the study in which Dan Markingson committed suicide  was not simply a matter of inadequate informed consent, or financial  conflicts of interest, or even failure to monitor a subject&rsquo;s care. The  ethical breach was built into the study from the start. It is one thing  to ask people to take risks for science, or the common good, or to help  other people. It is another thing entirely to ask them to risk their  lives for the marketing goal of [the sponsoring drug company]  AstraZeneca<\/em><\/font><\/strong><strong><em>&quot; &hellip;<\/em><\/strong><\/div>\n<\/ol>\n<\/ul>\n<div align=\"justify\"><img decoding=\"async\" width=\"190\" vspace=\"4\" hspace=\"4\" border=\"1\" align=\"right\" title=\"Dan Markingson with his mother and girlfriend, 2001\" alt=\"Dan Markingson with his mother and girlfriend, 2001\" src=\"http:\/\/t1.gstatic.com\/images?q=tbn:ANd9GcRmNhkYIVrLw653XEDXef_X4WVcmJG-mbdrAwI-GyZ5t5p2zrY&#038;t=1&#038;usg=__0jC7daq129OysU0JwhiyzUEw1-I=\" \/>The  medications known as the &quot;atypical antipsychotics&quot; were originally  touted as being less toxic that the traditional drugs we used to treat  psychosis. Fact is, it just isn&rsquo;t true. But these drugs have all but  replaced the older drugs, even though they are much more expensive. And  worse, they have become widely used in illnesses other than  Schizophrenia bringing in huge profits to their manufacturers even  though their toxicity does not justify their widespread use. Even big  paypouts from successful suits against the pharmaceutical companies for  false advertising and harmful effects on patients have made little dent  in the profitability of the drugs. Dan Markingson died needlessly in a  study focused only on increasing market shares.<\/div>\n<\/blockquote>\n<div align=\"justify\">See also the recent findings of outright fraud in that case [<a href=\"http:\/\/1boringoldman.com\/index.php\/2013\/02\/28\/living-history\/\" target=\"_blank\">living history&hellip;<\/a>]. As a profession, we owe it to his memory and his mother for Dan&#8217;s senseless death to mean something to the patients in future clinical trials&#8230;<\/div>\n","protected":false},"excerpt":{"rendered":"<p>If you don&#8217;t know about the Dan Markingson Case, it&#8217;s worth looking into. The icon on the left sidebar takes you to a petition to the Governor of Minnesota requesting an complete investigation. Carl Elliott has pressed for an investigation with little success and has now set up a petition to the Minnesota Governor asking [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-34166","post","type-post","status-publish","format-standard","hentry","category-politics"],"_links":{"self":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/34166","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/comments?post=34166"}],"version-history":[{"count":11,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/34166\/revisions"}],"predecessor-version":[{"id":34188,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/34166\/revisions\/34188"}],"wp:attachment":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/media?parent=34166"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/categories?post=34166"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/tags?post=34166"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}