{"id":41878,"date":"2013-11-27T23:00:30","date_gmt":"2013-11-28T04:00:30","guid":{"rendered":"http:\/\/1boringoldman.com\/?p=41878"},"modified":"2013-11-28T02:48:19","modified_gmt":"2013-11-28T07:48:19","slug":"risk-benefit-ratio","status":"publish","type":"post","link":"https:\/\/1boringoldman.com\/index.php\/2013\/11\/27\/risk-benefit-ratio\/","title":{"rendered":"risk benefit ratio…"},"content":{"rendered":"
I appreciate Peggi’s recent comment<\/a> on the blogs about Statins [an exempler…<\/a>, but I should’ve…<\/a>]. It highlights the subjective but central issue of the risk·benefit ratio<\/font><\/em><\/strong>:<\/div>\n
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When one is trying simply to be an informed patient and has become aware of all this corruption and COI in so many aspects of medicine, how on earth can a sound decision about medication be made? My internist wants me on statins; I have familial hypercholesterolemia and a family history of heart disease but I don’t smoke, I’m not overweight, I exercise, and I eat a fairly healthy diet. My blood pressure is okay. So how do I know whether or not I need to be taking a statin? This is all very confusing for those of us attempting to be good “consumers.” It’s tempting just to say I’ll take my chances and not take anything that’s advertised!<\/div>\n<\/blockquote>\n
She brings up a major collateral damage from the pharma influenced guidelines that broaden their market and profits geometrically – undermining the effective practice of medicine. The discovery of the Familial Hyperlipidemias was a major contribution of research to clinical practice, resulting in a Nobel Prize in 1985. Here’s a brief summary and appeal for more vigilance in the medical community: <\/div>\n
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Easily Missed? Familial hypercholesterolaemia<\/a><\/div>\n
by Peter J Gill, MD\/PhD student<\/em>, Anthony Harnden, university lecturer in general practice<\/em>, and Fredrik Karpe, professor of metabolic medicine<\/em><\/div>\n
British Medical Journal<\/font><\/strong>. 2012 344:e3228.<\/div>\n

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What is familial hypercholesterolaemia?<\/font><\/strong><\/p>\n

Familial hypercholesterolaemia is an inherited autosomal dominant genetic disorder characterised by high serum cholesterol concentrations detectable at a young age. It is associated with early cardiovascular disease, and an underlying genetic cause can be identified in about 80% of cases.<\/p>\n

How common is familial hypercholesterolaemia?<\/font><\/strong><\/div>\n