{"id":42901,"date":"2014-01-04T21:59:23","date_gmt":"2014-01-05T02:59:23","guid":{"rendered":"http:\/\/1boringoldman.com\/?p=42901"},"modified":"2014-01-04T22:02:24","modified_gmt":"2014-01-05T03:02:24","slug":"caberet","status":"publish","type":"post","link":"https:\/\/1boringoldman.com\/index.php\/2014\/01\/04\/caberet\/","title":{"rendered":"caberet&#8230;"},"content":{"rendered":"\n<p align=\"justify\" class=\"small\"><em>I think Deep Throat&#8217;s line, &quot;Follow the money,&quot; was a bit of fiction from screenwriter William Goldman rather than historical fact, but it doesn&#8217;t matter. It captured a principle that may well outlive its origins. Here, Ginny Barbour uses it with finesse:<\/em><\/p>\n<blockquote>\n<div align=\"center\" class=\"big\"><a href=\"http:\/\/blogs.plos.org\/speakingofmedicine\/2014\/01\/03\/follow-the-money-or-why-it-took-an-accounts-committee-to-decide-why-access-to-clinical-trial-data-matters\/#.UsbpbE-F0tc.twitter\" target=\"_blank\">Follow the Money; or, Why it Took an Accounts Committee to Decide Why Access to Clinical Trial Data Matters<\/a><\/div>\n<div align=\"center\" class=\"big\"><strong><font color=\"#660000\">PLoS blogs <\/font><\/strong><\/div>\n<div align=\"center\" class=\"middle\">By Virginia Barbour<\/div>\n<div align=\"center\" class=\"small\">January 3, 2014<\/div>\n<div align=\"center\" class=\"small\"><em>Ginny Barbour, Medicine Editorial Director at PLOS,  discusses a recently-published UK Government spending report on access  to clinical trial information and the stockpiling of Tamiflu.<\/em><\/div>\n<p>           <\/p>\n<div align=\"justify\">Yesterday the <a target=\"_blank\" href=\"http:\/\/www.parliament.uk\/pac\">UK Parliament&rsquo;s Public Accounts Committee<\/a>,  which monitors UK Government spending &ndash; focusing on &ldquo;value-for-money  criteria which are based on economy, effectiveness and efficiency&rdquo;&nbsp;&ndash;  published a rather amazing report; not just because of the topic of its  enquiry but in particular its conclusions, which have implications well  beyond the UK. The topic was &ldquo;<a target=\"_blank\" href=\"http:\/\/www.publications.parliament.uk\/pa\/cm201314\/cmselect\/cmpubacc\/295\/29502.htm\">Access to clinical trial information and the stockpiling of Tamiflu<\/a>&rdquo;:  the conclusions were that the money spent on Tamiflu was likely  misspent, and moreover the lack of access to clinical trial data more  widely is unacceptable.<\/div>\n<div align=\"center\"><img loading=\"lazy\" decoding=\"async\" height=\"18\" width=\"66\" border=\"0\" src=\"http:\/\/1boringoldman.com\/images\/snip.gif\" \/><\/div>\n<div align=\"justify\">Richard Bacon MP, member of the Committee of Public Accounts, said in  &nbsp;quote which succinctly sums up how unacceptable the current position  is :<\/div>\n<ul>\n<div align=\"justify\">&ldquo;The full results of clinical trials are being routinely and legally  withheld from doctors and researchers by the manufacturers of  medicines.&nbsp;This has ramifications for the whole of medicine. The ability  of doctors, researchers and patients to make informed decisions about  treatments is being undermined. Regulators and the industry have  recently made proposals to open up access, but these do not cover the  issue of access to the results of trials in the past which bear on the  efficacy and safety of medicines in use today.&rdquo;<\/div>\n<\/ul>\n<div align=\"justify\">Or, as the report&rsquo;s summary says<\/div>\n<ul>\n<div align=\"justify\">&ldquo;This longstanding regulatory&nbsp;and cultural failure  impacts on all of medicine, and undermines the ability of  clinicians,&nbsp;researchers and patients to make informed decisions about  which treatment is best.&rdquo;<\/div>\n<\/ul>\n<div align=\"justify\">AllTrials, a coalition spearheaded by Ben Goldacre [doctor and author of <a target=\"_blank\" href=\"http:\/\/www.badscience.net\/2013\/12\/free-here-is-the-new-what-happened-next-update-chapter-from-bad-pharma-2013\/\">Bad Pharma<\/a>], the charity <a target=\"_blank\" href=\"http:\/\/www.senseaboutscience.org\/\">Sense About Science<\/a>,&nbsp;the <a target=\"_blank\" href=\"http:\/\/www.bmj.com\/\"><em>BMJ<\/em><\/a>, <a target=\"_blank\" href=\"http:\/\/www.plos.org\/\">PLOS<\/a>  [where I am the Medicine Editorial Director] and a group of independent  academics, was born out of real anger that the many backroom  discussions on trials were simply going nowhere and there was a need to  bring the issue of hidden data into the public view. The campaign has  been successful in mobilizing academics and patients groups, has lobbied  UK and European Parliamentarians and overall has been a key reason in  the movement toward more transparency of a number of pharmaceutical  companies.<\/div>\n<p align=\"justify\"><strong><font color=\"#100010\">It&rsquo;s ironic in the end though that it may take a Committee whose job  it is to look at spending to point out what Health Departments seems to  have been willing to ignore &ndash; that hiding clinical trial data is  tremendously damaging to society, at an individual, professional and  yes, even a financial level.<\/font><\/strong><\/p>\n<div align=\"justify\">Ben Goldacre sums it up thus:<\/div>\n<ul>\n<div align=\"justify\">&ldquo;We cannot make informed decisions about which treatment is best,  when vitally important information is routinely and legally kept secret.  Future generations will look back at this absurd situation in the same  way that we look back on mediaeval bloodletting.&rdquo;<\/div>\n<\/ul>\n<\/blockquote>\n<div align=\"justify\" class=\"small\"><a href=\"http:\/\/www.youtube.com\/watch?v=I8P80A8vy9I\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" hspace=\"4\" height=\"156\" width=\"120\" vspace=\"4\" border=\"1\" align=\"right\" src=\"http:\/\/1boringoldman.com\/images\/money.jpg\" \/><\/a>It&#8217;s not really so ironic, it&#8217;s the way the world works. Allen Jones ran across a funny account working as an investigator for the Pennsylvania OIG. The trail he followed ended up busting a mega-scam called TMAP, still under-prosecuted. How could we be surprised that it was the money spent by the British government on Tamiflu that finally revealed that the efficacy of the drug rested on selected clinical trials, and there were a raft of unpublished trials sitting in Roche&#8217;s file drawers? Joel Grey and Liza Manelli told us that &quot;Money makes the world go round&quot; a long time ago. Thus, the Pharmaceutical industry and friends have tainted the integrity of the medical profession as a whole keeping it spinning&#8230;<\/div>\n","protected":false},"excerpt":{"rendered":"<p>I think Deep Throat&#8217;s line, &quot;Follow the money,&quot; was a bit of fiction from screenwriter William Goldman rather than historical fact, but it doesn&#8217;t matter. It captured a principle that may well outlive its origins. Here, Ginny Barbour uses it with finesse: Follow the Money; or, Why it Took an Accounts Committee to Decide Why [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-42901","post","type-post","status-publish","format-standard","hentry","category-politics"],"_links":{"self":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/42901","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/comments?post=42901"}],"version-history":[{"count":17,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/42901\/revisions"}],"predecessor-version":[{"id":42918,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/42901\/revisions\/42918"}],"wp:attachment":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/media?parent=42901"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/categories?post=42901"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/tags?post=42901"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}