{"id":43134,"date":"2014-01-18T08:00:36","date_gmt":"2014-01-18T13:00:36","guid":{"rendered":"http:\/\/1boringoldman.com\/?p=43134"},"modified":"2014-01-19T15:14:28","modified_gmt":"2014-01-19T20:14:28","slug":"when","status":"publish","type":"post","link":"https:\/\/1boringoldman.com\/index.php\/2014\/01\/18\/when\/","title":{"rendered":"when?…"},"content":{"rendered":"\n
Back in November 2012 when I read the first of these Computerized Adaptive Test papers, I noted that it ended with:<\/div>\n
\n
Funding\/Support: This work was supported by grant R01-MH66302 from the National Institute of Mental Health…
Additional Information: The CAT-DI will ultimately be made available for routine administration, and its development as a commercial product is under consideration…<\/div>\n<\/blockquote>\n

and registered<\/a> a blip, but I didn’t have any idea the story would become so complex and convoluted. Here’s my blog log as I’ve tried to follow it: <\/p>\n\n\n
11\/09\/2012    really?…<\/a>
08\/12\/2013    a road to nowhere…<\/a>
11\/21\/2013    careful watching…<\/a>
12\/29\/2013    insider trading…<\/a>
01\/03\/2014    DSM-5 retrospective I…<\/a>
<\/span> <\/td>\n		 01\/03\/2014    DSM-5 retrospective II…<\/a>
01\/03\/2014    DSM-5 retrospective III…<\/a>
01\/06\/2014    royalty? …<\/a>
01\/11\/2014    top down problem…<\/a>
01\/16\/2014    why?…<\/a>
<\/span> <\/td>\n<\/tr>\n<\/table>\n

My last post [why? …<\/a><\/span>] was a transcript of an APA Memo in response to the revelation that the authors had not declared significant Conflicts of Interest while they were involved with the DSM-5 Task Force. I found that Memo way off point and started jotting down a timeline to organize my response, and that’s where yesterday went. So here’s my timeline for your perusal. I’ve thrown in a few short quotes from the selections, but the links connect to the real material. Rather than jump in with my thoughts, I’ve put it here for you read through yourself while I think about it too. It tells the story all by itself…<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
 <\/td>\nDate Public<\/font><\/strong><\/td>\n <\/td>\nSubmitted<\/font><\/strong><\/td>\nAccepted<\/font><\/strong><\/td>\nPublished<\/font><\/strong><\/td>\nDisclosure<\/font><\/strong><\/td>\n<\/tr>\n
\n
<\/td>\n<\/tr>\n
1<\/sup><\/td>\n07\/01\/1993<\/td>\nExactly what does the Hamilton Depression Rating Scale measure?<\/a>
by Gibbons RD, Clark DC, and Kupfer DJ.
Journal of Psychiatric Research. 1993 27(3):259-273.
"… the HDRS total score is a weak index of depressive syndrome severity. The findings provide a benchmark by which the adequacy of future results may be judged, because the multidimensional IRT model does not suffer from the statistical limitations that arise when applying traditional factor analytic methods to discrete symptom ratings…<\/em>" <\/td>\n<\/tr>\n
2<\/sup><\/td>\n2002-2010<\/td>\nCOMPUTERIZED ADAPTIVE TESTING – DEPRESSION INVENTORY<\/a>
NIMH Project MH066302
NIH RePORTER
"Total project funding amount for 9 projects is $4,958,346<\/em>" <\/td>\n<\/tr>\n
3<\/sup><\/td>\n2002<\/td>\nA Research Agenda for DSM-V<\/a>
edited by David J. Kupfer, Michael B. First, and Darrel A. Regier,
"DSM-IV and ICD-10 are both categorical classifications or typologies, and so were all their predecessors. In principle, though, variation in the symptomatology of mental disorder could be represented by a set of dimensions rather than by multiple categories…<\/em>" <\/td>\n<\/tr>\n
4<\/sup><\/td>\n11\/01\/2005<\/td>\n Dimensional Models for Research and Diagnosis: A Current Dilemma<\/a>
in Toward a Dimensionally Based Taxonomy of Psychopathology<\/em>
by Kupfer, David
Journal of Abnormal Psychology. 2005 114[4]:557-559.
"Ultimately, new methodological strategies need to be incorporated that address both categorical and dimensional aspects of the overall diagnostic framework. These refinements will be vital in determining the extent and reality of co-occurrence of disorder and the determination of boundaries across specific disorders.<\/em>" <\/td>\n<\/tr>\n
5<\/sup><\/td>\n04\/01\/2006 <\/td>\nKupfer appointed chair DSM-5 Task Force<\/font><\/strong><\/td>\n<\/tr>\n
6<\/sup><\/td>\n04\/01\/2008<\/td>\nUsing Computerized Adaptive Testing to Reduce the Burden of Mental Health Assessment<\/a>
by Robert D. Gibbons, David J. Weiss, David J. Kupfer, Ellen Frank, et al
Psychiatric Services 2008 59:361–368.
"Instead of using small fixed-length tests, clinicians can create item banks with a large item pool, and a small set of the items most relevant for a given individual can be administered with no loss of information, yielding a dramatic reduction in administration time and patient and clinician burden.<\/em>" <\/td>\n<\/tr>\n
7<\/sup><\/td>\n03\/27\/2009<\/td>\nDr. Jane Costello resigns from the DSM-5 Child and Adolescent Disorders workgroup<\/a>. In her letter of resignation<\/a>, she said:
"…The tipping point for me was the memo from David and Darrell on February 18, 2009, stating “Thus, we have decided that one if not the major difference between DSM-IV and DSM-V will be the more prominent use of dimensional measures inDSM-V”, and going on to introduce an Instrument Assessment Study Group that will advise workgroups on the choice of old scale measures or the creation of new ones.<\/em>" <\/td>\n<\/tr>\n
8<\/sup><\/td>\n unk<\/td>\nDrs. Robert Gibbons and Paul Pilkonis appointed as Expert Advisors to the<\/font><\/strong> Instrument Assessment Study Group<\/a><\/td>\n<\/tr>\n
9<\/sup><\/td>\n11\/29\/2011<\/td>\nPsychiatric Assessments Inc.<\/a> incorporated in Delaware<\/font><\/strong> [enter File #5072041].<\/td>\n<\/tr>\n
10<\/sup><\/td>\n01\/23\/2012<\/td>\nPsychiatric Assessments Inc.<\/a> incorporated in Illinois<\/font><\/strong> [enter File #68256313].<\/td>\n<\/tr>\n
11<\/sup><\/td>\n08\/31\/2012<\/td>\nYehuda Cohen, a professional management executive, registers Adaptive Testing Technologies<\/a> website. Mr. Cohen is featured as a principal on the corporate website.<\/a> .<\/td>\n<\/tr>\n
12<\/sup><\/td>\n10\/23\/2012<\/td>\nPrivacy Policy posted on the website<\/a>.<\/td>\n<\/tr>\n
13<\/sup><\/td>\n11\/01\/2012<\/td>\nDevelopment of a computerized adaptive test for depression<\/a>.
by Gibbons, Weiss, Pilkonis, Frank, Moore, Kim, and Kupfer.
Archives of General Psychiatry. 2012 69[11]:1104-12.
"Traditional measurement fixes the number of items administered and allows measurement uncertainty to vary. In contrast, a CAT fixes measurement uncertainty and allows the number of items to vary. The result is a significant reduction in the number of items needed to measure depression and increased precision of measurement.<\/em>" <\/td>\n<\/tr>\n
 <\/td>\n <\/td>\nPublication<\/font><\/strong> [CAT-DI]<\/td>\n08\/19\/2011<\/font><\/strong> <\/td>\n01\/04\/2012<\/font><\/strong> <\/td>\n11\/01\/2012<\/font><\/strong> <\/td>\nno<\/font><\/strong><\/td>\n<\/tr>\n
14<\/sup><\/td>\n12\/01\/2012<\/td>\nDSM-5 approved by the APA Trustees.<\/font><\/strong>
"Cross-Cutting Dimensions" moved to Section III [Emerging Measures and Models].<\/em><\/td>\n<\/tr>\n
15<\/sup><\/td>\n02\/25\/2013<\/td>\nThe Future Arrived<\/a>
by David J. Kupfer; Emily A. Kuhl; Darrel A. Regier.
JAMA. 2013 309[16]:1691-1692.
"The next revision of psychiatry’s Diagnostic and Statistical Manual of Mental Disorders [DSM-5] will be published in May 2013 and is the first revision of this psychiatric nomenclature in almost 2 decades…<\/em>" <\/td>\n<\/tr>\n
 <\/td>\n <\/td>\nPublication<\/font><\/strong> [DSM-5]<\/td>\n <\/font><\/strong> <\/td>\n <\/font><\/strong> <\/td>\n02\/25\/2013<\/font><\/strong> <\/td>\nno<\/font><\/strong><\/td>\n<\/tr>\n
16<\/sup><\/td>\n03\/02\/2013<\/td>\nDr. Kupfer’s lecture to ACP Virginia<\/a>
by David J. Kupfer
Dr. Kupfer’s lecture to ACP Virginia promoting the Dimensional Measures in DSM-5 [see slides 8, 17, 32, 34, & 36]. No disclosure of PAI\/ATT.<\/em><\/td>\n<\/tr>\n
 <\/td>\n <\/td>\nPresentation<\/font><\/strong> [slides]<\/td>\n <\/font><\/strong> <\/td>\n <\/font><\/strong> <\/td>\n03\/02\/2013<\/font><\/strong> <\/td>\nno<\/font><\/strong><\/td>\n<\/tr>\n
17<\/sup><\/td>\n05\/18\/2013<\/td>\nDSM-5 Published.<\/font><\/strong><\/td>\n<\/tr>\n
18<\/sup><\/td>\n07\/01\/2013 <\/td>\n Computerized Adaptive Test–Depression Inventory Not Ready for Prime Time<\/a>
by Bernard Carroll
JAMA Psychiatry. 2013 70[7]:763.
"The goal of commercial development seems premature; patients risk being “assayed” against a non–gold standard. Though CAT-DI may have been an interesting statistical challenge, it lacks a solid clinimetric grounding. It is not ready for clinical use…<\/em>" <\/td>\n<\/tr>\n
 <\/td>\n <\/td>\nPublication<\/font><\/strong> [letter]<\/td>\n11\/19\/2012 <\/font><\/strong> <\/td>\n11\/26\/2012 <\/font><\/strong> <\/td>\n07\/01\/2013 <\/font><\/strong> <\/td>\nyes<\/font><\/strong><\/td>\n<\/tr>\n
19<\/sup><\/td>\n07\/01\/2013 <\/td>\n Computerized Adaptive Test–Depression Inventory Not Ready for Prime Time: In Reply<\/a>
by Gibbons, Weiss, Pilkonis, Frank, Moore, Kim, and Kupfer
JAMA Psychiatry. 2013 70[7]:763-765
"In this case, it is Carroll who has theoverwhelming conflict of interest.As developer,owner,and marketer of the Carroll Depression Scale–Revised, a traditional fixed-length test, it is not surprising that the paradigm shift described in our article would be of serious concern to him.<\/em>" <\/td>\n<\/tr>\n
 <\/td>\n <\/td>\nPublication<\/font><\/strong> [reply]<\/td>\n <\/font><\/strong> <\/td>\n <\/font><\/strong> <\/td>\n07\/01\/2013 <\/font><\/strong> <\/td>\nno<\/font><\/strong><\/td>\n<\/tr>\n
20<\/sup><\/td>\n07\/01\/2013 <\/td>\nThe Computerized Adaptive Diagnostic Test for Major Depressive Disorder [CAD-MDD]: A Screening Tool for Depression<\/a>
by Gibbons, Hooker, Finkelman, Weiss, Pilkonis, Frank, Moore, and Kupfer.
Journal of Clinical Psychiatry. 2013 74[7]:669–674.
"Inexpensive [relative to clinical assessment], efficient, and accurate screening of depression in the settings of primary care, psychiatric epidemiology, molecular genetics, and global health are all direct applications of the current system.<\/em>" <\/td>\n<\/tr>\n
 <\/td>\n <\/td>\nPublication<\/font><\/strong> [CAD-MDD]<\/td>\n12\/20\/2012 <\/font><\/strong> <\/td>\n04\/05\/2013 <\/font><\/strong> <\/td>\n07\/01\/2013 <\/font><\/strong> <\/td>\nyes<\/font><\/strong><\/td>\n<\/tr>\n
21<\/sup><\/td>\n08\/09\/2013<\/td>\nDevelopment of the CAT-ANX: A Computerized Adaptive Test for Anxiety<\/a>
by Gibbons, Weiss, Pilkonis, Frank, Moore, Kim, and Kupfer.
American Journal of Psychiatry. published on-line Aug 9, 2013
"Potential applications for inexpensive, efficient, and accurate screening of anxiety in primary care settings, clinical trials, psychiatric epidemiology, molecular genetics, children, and other cultures are discussed.<\/em>" <\/td>\n<\/tr>\n
 <\/td>\n <\/td>\nPublication<\/font><\/strong> [CAT-ANX]<\/td>\n02\/08\/2013<\/font><\/strong> <\/td>\n05\/06\/2013<\/font><\/strong> <\/td>\n08\/09\/2013<\/font><\/strong> <\/td>\nyes<\/font><\/strong><\/td>\n<\/tr>\n
22<\/sup><\/td>\n08\/20\/2013<\/td>\nDr. Carroll’s letter to JAMA Psychiatry<\/a>
This letter was provided by Dr. Carroll at my request – 1boringoldman<\/em><\/td>\n<\/tr>\n
 <\/td>\n <\/td>\n[letter]<\/td>\n08\/20\/2013<\/font><\/strong> <\/td>\nrejected<\/font><\/strong> <\/td>\nunpublished<\/font><\/strong> <\/td>\nyes<\/font><\/strong><\/td>\n<\/tr>\n
23<\/sup><\/td>\n10\/09\/2013<\/td>\nThe Future of Mental Health Diagnostic Screening<\/a> [click on page 4]
PsychsTalk Blog: CME Institute
by Robert Gibbons, Ellen Frank, and David Kupfer.
"… The CAD-MDD and related CAT-DI and CAT-ANX share goals similar to those of the new version of DSM: they seek to improve screening and assessment of mental health disorders in a number of ways for patients, clinicians, and caregivers, including decreasing clinician and patient burden. The third section of DSM-5 is aimed at providing tools for cross-cutting and dimensional assessment, often involving patient-reported outcomes. The electronic version of the DSM-5 will allow for the development and application of many more scales and certainly better possibilities for tracking change and the effectiveness of treatment. Another objective of DSM-5 is to improve the interface with the rest of medicine, especially primary care…<\/em>" <\/td>\n<\/tr>\n
 <\/td>\n <\/td>\nPublication<\/font><\/strong> [CME]<\/td>\n <\/font><\/strong> <\/td>\n <\/font><\/strong> <\/td>\n10\/09\/2013<\/font><\/strong> <\/td>\nyes<\/font><\/strong><\/td>\n<\/tr>\n
24<\/sup><\/td>\n11\/20\/2013<\/td>\nFailure to Report Financial Disclosure Information<\/a>
by Gibbons, Weiss, Pilkonis, Frank, and Kupfer.
JAMA Psychiatry. 2013 71[1]:95.
"To the Editor We apologize to the editors and readers of JAMA Psychiatry for our failure to fully disclose our financial interests in an article that reported a diagnostic tool, the Computerized Adaptive Test for Depression [CAT-DI]… Lead author Robert D. Gibbons, PhD, is the president and founder of PAI, which was incorporated in Delaware in late 2011, then registered to do business in Illinois in January 2012. Dr Gibbons awarded “founder’s shares in PAI” to us, yet all 5 of us failed to report our financial interests in connection with our article and again in a Reply to Letters to the Editor regarding the article… Our submitted disclosure lacked transparency, and we regret our omission.<\/em>" <\/td>\n<\/tr>\n
25<\/sup><\/td>\n11\/21\/2013<\/td>\n When is Disclosure Not Disclosure?<\/a>
Healthcare Renewal
by Bernard Carroll
"Here is a case study in conflict of interest [COI]. A remarkable confession has just appeared by a group of 5 prominent academics, writing in the journal JAMA Psychiatry. Having been outed to the Editors, they now admit to concealing pertinent financial information. One of the five is David J. Kupfer, MD, chairman of the DSM-5 Task Force and past chairman of the department of psychiatry at The University of Pittsburgh…<\/em>" <\/td>\n<\/tr>\n
26<\/sup><\/td>\n12\/23\/2013<\/td>\n DSM-5 – Dimensional Diagnoses – More Conflicts of Interest?<\/a>
Behaviorism and Mental Health
by Phil Hickey
"… why hasn’t Dr. Kupfer issued some kind of explanation for the lack of transparency? The JAMA Psychiatry letter of apology was just a stark statement of fact, which leaves a huge cloud of doubt not only over Dr. Kupfer, but also over DSM-5 and psychiatry generally…<\/em>" <\/td>\n<\/tr>\n
27<\/sup><\/td>\n01\/14\/2014<\/td>\n Mindy Young, MD, Speaker <\/a>
Memo to APA Assembly members
APA Newsroom
"Dr. Kupfer should have disclosed to APA his interest in PAI in 2012. Dr. Kupfer’s interest in PAI, which came after the decision had been made to include dimensional measures in DSM-5, did not influence DSM-5’s inclusion of dimensional measures for further study in Section 3. Interest in inclusion of these measures in DSM-5 began with conferences starting in 2003. If and when PAI develops a commercial product with CAT, it will not have any greater advantage than the dozens of dimensional measures currently being marketed by others.<\/em>" <\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Back in November 2012 when I read the first of these Computerized Adaptive Test papers, I noted that it ended with: Funding\/Support: This work was supported by grant R01-MH66302 from the National Institute of Mental Health… Additional Information: The CAT-DI will ultimately be made available for routine administration, and its development as a commercial product […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-43134","post","type-post","status-publish","format-standard","hentry","category-politics"],"_links":{"self":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/43134","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/comments?post=43134"}],"version-history":[{"count":143,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/43134\/revisions"}],"predecessor-version":[{"id":43320,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/43134\/revisions\/43320"}],"wp:attachment":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/media?parent=43134"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/categories?post=43134"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/tags?post=43134"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}