{"id":56894,"date":"2015-05-15T08:00:17","date_gmt":"2015-05-15T12:00:17","guid":{"rendered":"http:\/\/1boringoldman.com\/?p=56894"},"modified":"2015-05-15T07:27:19","modified_gmt":"2015-05-15T11:27:19","slug":"why-13","status":"publish","type":"post","link":"https:\/\/1boringoldman.com\/index.php\/2015\/05\/15\/why-13\/","title":{"rendered":"why not <u>also<\/u>?&#8230;"},"content":{"rendered":"<div align=\"justify\" class=\"small\"><img decoding=\"async\" vspace=\"2\" hspace=\"4\" height=\"180\" border=\"1\" align=\"right\" src=\"http:\/\/1boringoldman.com\/images\/so-long.jpg\" \/>In a recent discussion about the origin of the <em><strong><font color=\"#200020\">chemical imbalance<\/font><\/strong><\/em> notion of depression [see <a target=\"_blank\" href=\"http:\/\/1boringoldman.com\/index.php\/2015\/05\/03\/guilding-the-lilly\/\">guilding the lily&hellip;<\/a>], I mentioned a <strong><font color=\"#0066ff\">BMJ<\/font><\/strong> Editorial by David Healy [available online]&#8230;<\/div>\n<ul><span class=\"small\">           <\/p>\n<li>\n<div align=\"justify\"><em><a target=\"_blank\" href=\"http:\/\/davidhealy.org\/wp-content\/uploads\/2015\/04\/2015-So-Long-and-Thanks-for-all-the-Serotonin-bmj.h1771.pdf\">Serotonin and depression: The marketing of a myth<\/a><\/em><br \/>                 <sup><strong><font color=\"#200020\">British Medical Journal<\/font><\/strong>; by David Healy; April 21, 2015.<\/sup><\/div>\n<\/li>\n<p>         <\/span><\/ul>\n<div align=\"justify\" class=\"small\">&#8230; that ends with &quot;<font color=\"#200020\"><em>so long, and thanks for all the Serotonin<\/em><\/font>&quot; &#8211; an allusion to Douglas Adams&#8217; <font color=\"#200020\">So Long, And Thanks For All The Fish<\/font> [the fourth book in the <font color=\"#200020\">Hitchhiker&#8217;s Guide to the Galaxy<\/font> Trilogy]. It&#8217;s what the Dolphins said when they disappeared from earth, knowing that the earth was about to be destroyed &#8211; for good. It&#8217;s the kind of finality he&#8217;s suggesting we put on the Serotonin Depression Myths&#8230;  <\/div>\n<p>       <\/p>\n<div align=\"justify\" class=\"small\">In his response yesterday to various comments, Dr. Healy is much more direct and speaks to a very obvious point:      <\/div>\n<ul><span class=\"small\">           <\/p>\n<li>\n<div align=\"justify\"><em><a target=\"_blank\" href=\"http:\/\/www.bmj.com\/content\/350\/bmj.h2510\">Author&rsquo;s reply to Langford, Cowen, Chekroud and Krystal<\/a><\/em><br \/>                 <sup><strong><font color=\"#200020\">British Medical Journal<\/font><\/strong>; by David Healy; May 14, 2015.<\/sup><\/div>\n<\/li>\n<p><\/span><\/ul>\n<blockquote>\n<div align=\"justify\">I wrote an almost identical editorial in 1991. Covering the marketing of serotonin in 1997, I cited Jerome Gaub&rsquo;s 1767 opinion of Leibniz&rsquo;s views on the relations between mind and body&mdash;it is a &ldquo;fable whose novelty has recommended it, whose recommendation has spread it, whose spread has polished it, refined and adorned it with &#8230; a pleasing look of truth.&rdquo; <\/div>\n<p align=\"justify\">I use selective serotonin reuptake inhibitors [SSRIs]. Nevertheless I believe the SSRI era will soon stand as one of the most shameful in the history of medicine. The shame does not stem from what drug companies have done, which is only what might have been expected, but from the failure of doctors to know as much as they should have done about drugs they dish out so liberally. A recent study showing how a dollop of neuroscience dressing can disguise otherwise meaningless material should be compulsory reading for doctors who are, after all, the true consumers of these drugs.<\/p>\n<div align=\"justify\"><em><strong><font color=\"#200020\">But perhaps an even greater shame will be seen to lie with the fact that, during this era, most publications on on-patent drugs in our best journals were ghost-written<\/font><\/strong><\/em>. In addition, during this time journals refused to demand access to trial data as the price for publication &mdash; this is most clearly demonstrated in the area of antidepressant studies on children. It has been an era when industry has controlled journals, by spending money on some of them and by intimidating others.<\/div>\n<\/blockquote>\n<div align=\"justify\" class=\"small\">I heartily agree. And while this is one of the more important announcements we&#8217;ve heard recently [and I applaud the decision]&#8230;<\/div>\n<blockquote>\n<div align=\"center\" class=\"big\"><a target=\"_blank\" href=\"http:\/\/www.bmj.com\/content\/350\/bmj.h2373\">The BMJ requires data sharing on request for all trials<\/a><\/div>\n<div align=\"center\" class=\"small\">by Elizabeth Loder and Trish&nbsp; Groves<\/div>\n<div align=\"center\" class=\"middle\"><strong><font color=\"#0066ff\">British Medical Journal<\/font><\/strong>. 2015 350:h2373<\/div>\n<p align=\"justify\">Heeding calls from the Institute of Medicine, WHO,  and the Nordic Trial Alliance, we are extending our policy. The   movement to make data from clinical trials widely accessible has   achieved enormous success, and it is now time for medical journals to   play their part. From 1 July <em>The BMJ<\/em> will extend its   requirements for data sharing to apply to all submitted clinical trials,   not just those that test drugs or devices. The data transparency  revolution is gathering pace.<a href=\"http:\/\/www.bmj.com\/content\/350\/bmj.h2373#ref-2\">2<\/a>   Last month, the World Health Organization [WHO] and the Nordic Trial   Alliance released important declarations about clinical trial   transparency.<\/p>\n<p align=\"justify\">These  announcements come on the heels of the US  Institute of Medicine&rsquo;s [IOM]  report on sharing clinical trial data,  which called for a  transformation of existing scientific culture to one  where &ldquo;data sharing  is the expected norm.&rdquo;  The efforts of industry,  too, must be acknowledged, some of which  caught many people by  surprise. In particular, Medtronic&rsquo;s cooperation  with the Yale  University Open Data project and GlaxoSmithKline&rsquo;s  leadership on data  disclosure efforts stand out.<\/p>\n<p align=\"justify\">WHO&rsquo;s  statement on public disclosure of clinical  trial results and the  accompanying rationale reiterate the  organisation&rsquo;s support for  registration of clinical trials.  WHO  declares that the main results of clinical trials should be posted  on a  clinical trial registry or other acceptable website and submitted  for  journal publication within a year of study completion. The  expectation  is that results will be &ldquo;made available publicly at most  within 24  months of completion.&rdquo; The statement does not call for  mandatory  sharing of primary data from trials but instead &ldquo;encourages&rdquo;  sharing of  research datasets &ldquo;whenever appropriate.&rdquo;<\/p>\n<div align=\"justify\">In a move that is particularly welcomed by Ben  Goldacre, cofounder of the AllTrials campaign,  WHO also recommends  disclosure of previously conducted but unreported  clinical trials in a  searchable and free registry and says it is  &ldquo;desirable&rdquo; that these  trials should be published in a peer reviewed  journal. Goldacre notes  that this is important because &ldquo;the overwhelming  majority of  prescriptions today are for treatments that came onto the  market &mdash; and  were therefore researched &mdash; over the preceding decades rather  than the  past five years&rdquo;&hellip;<\/div>\n<\/blockquote>\n<div align=\"justify\" class=\"small\">&#8230; why not <u>also<\/u> say, &quot;<strong><em><font color=\"#200020\">NO GHOST WRITTEN ARTICLES ACCEPTED? If discovered after the fact, they will be retracted!<\/font><\/em><\/strong> <strong><em><font color=\"#200020\">noisily!<\/font><\/em><\/strong>&quot; <\/div>\n","protected":false},"excerpt":{"rendered":"<p>In a recent discussion about the origin of the chemical imbalance notion of depression [see guilding the lily&hellip;], I mentioned a BMJ Editorial by David Healy [available online]&#8230; Serotonin and depression: The marketing of a myth British Medical Journal; by David Healy; April 21, 2015. &#8230; that ends with &quot;so long, and thanks for all [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[5],"tags":[],"class_list":["post-56894","post","type-post","status-publish","format-standard","hentry","category-opinion"],"_links":{"self":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/56894","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/comments?post=56894"}],"version-history":[{"count":33,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/56894\/revisions"}],"predecessor-version":[{"id":56920,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/56894\/revisions\/56920"}],"wp:attachment":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/media?parent=56894"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/categories?post=56894"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/tags?post=56894"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}