{"id":60230,"date":"2015-09-28T16:20:22","date_gmt":"2015-09-28T20:20:22","guid":{"rendered":"http:\/\/1boringoldman.com\/?p=60230"},"modified":"2015-09-28T16:21:31","modified_gmt":"2015-09-28T20:21:31","slug":"study-329-xi-week-8","status":"publish","type":"post","link":"https:\/\/1boringoldman.com\/index.php\/2015\/09\/28\/study-329-xi-week-8\/","title":{"rendered":"study 329 xi – week 8…"},"content":{"rendered":"\n

I know I’m a broken record with this 329 stuff. ‘Blog’ came from parsing ‘Weblog’ into ‘We Blog’ – and when push comes to shove, all you can write about is what’s in your mind. This is what’s in there right now [still]…<\/font><\/em><\/sup><\/p>\n

In study 329 ix – mystic statistics…<\/a> I was talking about the variables reported ib the Keller et al paper that weren’t in the original protocol, the ones that were reported to be statistically significant. They’re highlighted in blue in this copy of their Table 2:<\/p>\n

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We left them out of the paper because we wanted to emphasize that they weren’t mentioned until near the end of the study. But in looking at them, when we looked at them post hoc, only three of the for survived using the protocol defined Anova analysis [the K-SADS-L Depressed Mood Item<\/font> bit the dust]. Two were barely over the p<0.05 line [or on it], and were only significant in week 8 of the study. <\/p>\n

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The notion that you would take some pill for two months and all of a sudden it would just start working seemed pretty remote to me. But I didn’t pay a lot of attention to the HAM-D Depressed Mood Item. After all, it was significant at the p<0.01 level in our analysis. But there was a Rapid Response to our article in the BMJ that had something to do with the HAM-D Depressed Mood Item causing me to go back for yet another look [Study 329 did detect an antidepressant signal from paroxetine<\/a>]. First, look at the graph on the left below. It’s the difference between the HAM-D Depressed Mood Item and the baseline value, and it doesn’t make any sense. It says Paroxetine is effective at the first week with a respectable p<\/em>=0.021 and an effect size of d<\/em>=0.39 [in the moderate range]. No antidepressant does that. And none of the other outcome variables show anything like that:<\/p>\n

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The HAM-D Depressed Mood Item is neither a continuous nor categorical [yes\/no] variable. It’s an Ordinal with five levels for the rater to choose from:<\/div>\n