{"id":65769,"date":"2016-05-22T11:15:40","date_gmt":"2016-05-22T15:15:40","guid":{"rendered":"http:\/\/1boringoldman.com\/?p=65769"},"modified":"2016-05-22T11:15:40","modified_gmt":"2016-05-22T15:15:40","slug":"publication-bias-a-post-script","status":"publish","type":"post","link":"https:\/\/1boringoldman.com\/index.php\/2016\/05\/22\/publication-bias-a-post-script\/","title":{"rendered":"publication bias &#8211; a post-script&#8230;"},"content":{"rendered":"<p align=\"justify\" class=\"small\">Wading around in the meta-analyses comparing antidepressant efficacy and safety among them can be like Kafka&#8217;s <font color=\"#200020\">The Trial<\/font> or McCarthy&#8217;s<font color=\"#200020\"> The Road.<\/font> You&#8217;re never sure where you are or if you&#8217;ve arrived anywhere. One of the most quoted versions is Cipriani et al&#8217;s <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19185342\" target=\"_blank\">Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis<\/a> that produced this chart.<\/p>\n<div align=\"center\"><em><font color=\"#200020\"><sup>Note, this ranking has been challenged [<a target=\"_blank\" href=\"http:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0063509\">Efficacy of New Generation Antidepressants: Differences Seem Illusory<\/a>]&#8230;<\/sup><\/font><\/em><\/div>\n<div align=\"center\"><img decoding=\"async\" width=\"450\" vspace=\"5\" border=\"0\" src=\"http:\/\/1boringoldman.com\/images\/ads-comp.gif\" \/><\/div>\n<div align=\"justify\" class=\"small\">&#8230;comparing efficacy and acceptability. The abcsissa [horizontal axis] is the rank from 1st down to 12th and the ordinate [vertical axis] is the probability of each rank for the drugs. Now recall this forest plot of Vortioxetine versus comparators [Duloxetine] from Cosgrove et al:  <\/div>\n<div align=\"center\"><img loading=\"lazy\" decoding=\"async\" width=\"450\" vspace=\"5\" height=\"327\" border=\"0\" src=\"http:\/\/1boringoldman.com\/images\/cos-2.gif\" \/><\/div>\n<div align=\"justify\" class=\"small\">They went head to head with one of their least effective rivals &#8211; and lost. New isn&#8217;t necessarily better&#8230;<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Wading around in the meta-analyses comparing antidepressant efficacy and safety among them can be like Kafka&#8217;s The Trial or McCarthy&#8217;s The Road. You&#8217;re never sure where you are or if you&#8217;ve arrived anywhere. One of the most quoted versions is Cipriani et al&#8217;s Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis that [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[5],"tags":[],"class_list":["post-65769","post","type-post","status-publish","format-standard","hentry","category-opinion"],"_links":{"self":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/65769","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/comments?post=65769"}],"version-history":[{"count":9,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/65769\/revisions"}],"predecessor-version":[{"id":65778,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/65769\/revisions\/65778"}],"wp:attachment":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/media?parent=65769"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/categories?post=65769"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/tags?post=65769"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}