{"id":6868,"date":"2011-04-05T13:02:27","date_gmt":"2011-04-05T17:02:27","guid":{"rendered":"http:\/\/1boringoldman.com\/?p=6868"},"modified":"2011-04-05T13:36:22","modified_gmt":"2011-04-05T17:36:22","slug":"a-slow-learner","status":"publish","type":"post","link":"https:\/\/1boringoldman.com\/index.php\/2011\/04\/05\/a-slow-learner\/","title":{"rendered":"a slow learner&#8230;"},"content":{"rendered":"\n<p align=\"justify\">As a child, I noticed that we had an odd book on our shelf &#8211; <strong><font color=\"#200020\">Mein Kampf<\/font><\/strong> by Adolf Hitler. When I got old enough to know what the book was about, I asked my Mom why she had it. She said she bought it&nbsp; during the war to find out what Hitler said that got a whole country to go crazy, but she kept it for me. She said that when I was older, she hoped I&#8217;d read it to understand what had happened, so it would never happen again. Later in my youth, I did read it. What I understood even back then was Hitler&#8217;s trick [and my mother&#8217;s wisdom]. There was something wrong in Germany, Hitler could feel it. As that theme built, against his own resistance to the idea, he gradually had to accept the inescapable conclusion that the something wrong was the Jews. And then the book turned monsterous as he outlined what he had in mind to do about that. You know the rest of the story. Decades later, as a Psychiatry Resident, I read it again &#8211; this time as a treatise on Paranoia written from the inside. And over the years as a Psychiatrist, when I hear a patient stringing together cherry-picked events aiming towards some conspiracy theory [becoming paranoid], in my mind I&#8217;ve thought of them as having the <em>Hitler feeling<\/em> &#8211; &quot;There&#8217;s something wrong and it&#8217;s dawning on me what it is.&quot;<\/p>\n<p align=\"justify\">I&#8217;ve only really had the <em>Hitler feeling<\/em> once myself &#8211; not that long ago. It was in September 2002 when the entire Bush Administration hit the airways one Sunday talking about Iraq and Saddam Hussein&#8217;s WMDs &#8211; the immediate danger right around the corner. I didn&#8217;t believe it. I thought it was a trick, and when I expressed my concerns, I got slammed as a non-patriot. Unfortunately, it was a trick. I was right that time &#8211; too right. It&#8217;s not a good thing, being right about a conspiracy theory. It makes you think you have some kind of keen intuition &#8211; fanning the flames of narcissism that hide inside us all.<\/p>\n<p align=\"justify\">So now I&#8217;ve got that Hitler feeling again. <strong><font color=\"#300030\">I think the Pharmaceutical Industry is trying to get rid of Psychiatrists and get the treatment of the mentally ill into the hands of Primary Care Physicians who will prescribe a lot more of their products.<\/font><\/strong> There I&#8217;ve said it out loud. I feel better already. Beside the fact that this has already happened, what little clues have I cherry-picked to make me think such a thing? Well, I thought it when I read that Drs. Nemeroff and Schatzberg had signed on to a industry-funded, ghost-written book, called <strong><font color=\"#200020\">Recognition and Treatment of Psychiatric Disorders: A Psychopharmacology Handbook for Primary Care<\/font><\/strong> [<u><strong><a href=\"http:\/\/1boringoldman.com\/wp-admin\/..\/index.php\/2010\/12\/05\/a-worthy-cause\/\" target=\"_blank\">a worthy cause&hellip;<\/a><\/strong><\/u>].<\/p>\n<p align=\"center\"><img decoding=\"async\" width=\"200\" border=\"0\" src=\"http:\/\/1boringoldman.com\/images\/recognition-1.jpg\" \/><br \/>          <sup>cover revised<\/sup><\/p>\n<p align=\"justify\"> And I thought it when I read some articles by a Dr. Trivedi in Texas about simple computer algorithms to direct treatment of Depression [<u><strong><a href=\"http:\/\/1boringoldman.com\/wp-admin\/..\/index.php\/2011\/01\/28\/evidence-based-medicine-i\/\" target=\"_blank\">evidence-based medicine I&hellip;<\/a><\/strong><\/u>].<\/p>\n<p align=\"center\"><img decoding=\"async\" width=\"400\" border=\"0\" src=\"http:\/\/1boringoldman.com\/images\/evidence-1.gif\" \/>&nbsp;<\/p>\n<p align=\"justify\">Then recently, I thought it when I read about Eli Lilly&#8217;s Viva Zyprexa campaign&nbsp; because they said it outright in some of their suggested sales pitches [<strong><a href=\"http:\/\/1boringoldman.com\/index.php\/2011\/03\/24\/zyprexa-the-other-early-years\"><font color=\"#6b2984\">Zyprexa<\/font>: the other early years&hellip;<\/a><\/strong>]:<\/p>\n<p align=\"center\"><img decoding=\"async\" width=\"400\" border=\"0\" src=\"http:\/\/1boringoldman.com\/images\/zyprexa-14.gif\" \/><\/p>\n<p align=\"center\"><img decoding=\"async\" width=\"400\" border=\"0\" src=\"http:\/\/1boringoldman.com\/images\/zyprexa-16.gif\" \/><\/p>\n<div align=\"justify\">Now I&#8217;m reviewing the NIMH funded <strong><font color=\"#300030\">STAR*D<\/font><\/strong> study on the treatment of depression [<strong><u><a target=\"_blank\" href=\"http:\/\/1boringoldman.com\/wp-admin\/..\/index.php\/2011\/04\/03\/a-thirty-five-million-dollar-misunderstanding\/\">a thirty-five million dollar misunderstanding&hellip;<\/a><\/u><\/strong>], and I&#8217;m feeling it again. Here&#8217;s Dr. Rush, first author on <strong><font color=\"#300030\">STAR*D<\/font><\/strong> [along with a Dr. Trivedi]: <\/div>\n<ul>\n<div align=\"center\"><a href=\"http:\/\/ajp.psychiatryonline.org\/cgi\/content\/full\/164\/2\/201\" target=\"_blank\"><strong><font color=\"#200020\">STAR*D: What Have We Learned?<\/font><\/strong><\/a><br \/>                 by A. John  Rush, M.D.<br \/>                 <strong><font color=\"#200020\">Am J Psychiatry<\/font><\/strong> 164:201-204, February 2007<\/div>\n<\/ul>\n<div>Let&#8217;s start at the end of his 2007 editorial:<\/div>\n<ul>\n<div align=\"justify\"><sup>Dr. Rush has served as an advisor, consultant, or speaker for or received research support from Advanced  Neuromodulation Systems, Inc.; Best Practice Project Management, Inc.; Bristol-Myers Squibb Company; Cyberonics, Inc.; Eli Lilly &amp; Company; Forest Pharmaceuticals, Inc.; Gerson Lehman Group; GlaxoSmithKline; Healthcare Technology Systems, Inc.; Jazz Pharmaceuticals; Merck &amp; Co., Inc.; the National Institute of Mental Health; Neuronetics; Ono Pharmaceutical; Organon USA Inc.; Personality Disorder Research Corp.; Pfizer Inc.; the Robert Wood Johnson Foundation; the Stanley Medical Research Institute; the Urban Institute; and Wyeth-Ayerst  Laboratories Inc. He has equity holdings in Pfizer Inc and receives royalty\/patent income from Guilford Publications and Healthcare Technology Systems, Inc.<\/sup><\/div>\n<div><strong><font color=\"#300030\">Dr. Freedman reviewed this editorial and found no evidence of influence from these relationships.<\/font><\/strong><\/div>\n<\/ul>\n<div align=\"justify\">Dr. Freedman was editor of the AJP in 2007, so it&#8217;s reassuring that he&#8217;s not bothered by Dr. Rush&#8217;s Conflicts of Interest and industry connections.&nbsp; Here are some cherry-picked quotes from Dr. Rush&#8217;s thoughts about <strong><font color=\"#300030\">STAR*D<\/font><\/strong>:<\/div>\n<ul>\n<div align=\"justify\"><sup>&bull; &quot;In addition, patients in primary care and psychiatric settings with major depression did not differ clinically except for slightly higher rates of general medical conditions in primary care settings, and slightly higher rates of prior suicide attempts in psychiatric settings.&quot;<\/sup><\/div>\n<div align=\"justify\"><sup>&bull; &quot;In terms of treatment tactics, STAR*D developed and implemented easily applied methods to enhance the quality of care in both daily practice and in clinical trials in representative groups of patients. This so-called &#8216;measurement-based care&#8217; entailed the routine use of simple paper-and-pencil symptom and side effect measures at each treatment visit, along with guidance based on these measures to recommend timely dose or treatment changes. A likely consequence of this high-quality, consistent care was that outcomes in primary care and psychiatric settings were not different.&quot;<\/sup><\/div>\n<div align=\"justify\"><sup>&bull; &quot;Logically, primary care providers are well positioned &mdash; if given the time, staff support, and reimbursement support to deliver high-quality, measurement-based care &mdash; to conduct the first two treatment steps. Thereafter, more complex drug regimens are likely needed; the gains are likely to be lower; and the evidence base is truly sparse. Perhaps these steps are best left to specialists.&quot;<\/sup><\/div>\n<\/ul>\n<div align=\"justify\">As reassured as I was by Dr. Freedman that Dr. Rush&#8217;s Industry connections weren&#8217;t influencing him, I thought I&#8217;d just write him about it, but, alas, he&#8217;s moved on to become the CEO of <strong><font color=\"#300030\">SCRI<\/font><\/strong> [<a target=\"_blank\" href=\"http:\/\/www.scri.edu.sg\/\"><u><strong><font color=\"#300030\">Singapore Clinical Research Institute<\/font><\/strong><\/u><\/a>], which seems to be a Clinical Research Center for drug trials in Singapore.<\/div>\n<div align=\"center\"><img decoding=\"async\" vspace=\"3\" border=\"0\" src=\"http:\/\/1boringoldman.com\/images\/rush.gif\" \/><\/div>\n<ul>\n<div align=\"justify\">ABOUT SCRI<br \/>  The second phase of Singapore&#8217;s  Biomedical Sciences Initiative focuses on expanding and strengthening  Singapore&#8217;s capabilities in translational and clinical research, which  are essential for translating research discoveries into clinical  applications that will improve health care.&nbsp;&nbsp;The development of a  national-level, academic research organisation like SCRI aids this goal  by filling an important gap in the development of human capital and  infrastructure.<\/div>\n<p align=\"justify\">SCRI houses an experienced and  highly-qualified team of scientists and research staff, offering a  comprehensive suite of clinical research capabilities. These areas of  expertise range from clinical project development&nbsp;to execution,  including protocol\/study design, project management, site monitoring,  data management, biostatistical analysis, epidemiology and evidence  synthesis, and training in various aspects of clinical research.<\/p>\n<div align=\"justify\">In driving towards its vision, SCRI  continues to enhance Singapore&rsquo;s clinical research capabilities and  strengthen its expertise in executing single and multi-site,  multi-national research&nbsp; developing regional clinical research networks.<\/div>\n<\/ul>\n<div align=\"justify\">Am I being facetious here, pretending to be paranoid, playing like Hitler? Damned right I&#8217;m being facetious! I&#8217;m not paranoid. I&#8217;m not Hitler. I&#8217;m just a slow learner. If you read <a href=\"http:\/\/ajp.psychiatryonline.org\/cgi\/content\/full\/164\/2\/201\" target=\"_blank\"><strong><font color=\"#200020\">STAR*D: What Have We Learned?<\/font><\/strong><\/a> all the way through, besides his plan to move treatment of depression from Psychiatry to Primary Care, Dr. Rush advocates treating people with milder symptoms, giving more medicines for longer periods, and giving combinations of medications from the very start. We&#8217;ll look further into <strong><font color=\"#300030\">STAR*D<\/font><\/strong> shortly, but I&#8217;ll jump ahead to say that none of these recommendations are remotely supported by his study. Dr. Freedman didn&#8217;t look hard enough. The authors of <strong><font color=\"#300030\">STAR*D <\/font><\/strong>are into the Drug Industry\/Clinical Trials Industry scene up to their necks, and are part of the campaign to reduce Mental Illness to simple symptom list treated with their precious drugs using algorithms not much more sophisticated than those of the chatty lady standing next to you in the drugstore aisle.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>As a child, I noticed that we had an odd book on our shelf &#8211; Mein Kampf by Adolf Hitler. When I got old enough to know what the book was about, I asked my Mom why she had it. She said she bought it&nbsp; during the war to find out what Hitler said that [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-6868","post","type-post","status-publish","format-standard","hentry","category-politics"],"_links":{"self":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/6868","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/comments?post=6868"}],"version-history":[{"count":24,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/6868\/revisions"}],"predecessor-version":[{"id":6892,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/posts\/6868\/revisions\/6892"}],"wp:attachment":[{"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/media?parent=6868"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/categories?post=6868"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/1boringoldman.com\/index.php\/wp-json\/wp\/v2\/tags?post=6868"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}