Plot summary: The life of spoiled Robert Merrick is saved through the use of a hospital’s only pulmotor, but because the medical device cannot be in two places at once, it results in the death of Dr. Hudson, a selfless, brilliant surgeon and generous philanthropist. Merrick falls in love with Hudson’s widow, Helen, though she […]
APA Attempts to Defend Itself Psychiatric Times By Allen Frances, MD December 5, 2011 This blog is a follow-up to an earlier post. The great news is that there is an active public debate on DSM-5. The leadership of the American Counseling Association [ACA] recently sent a thoughtful letter to the leadership of the American […]
Major Depressive Disorder Depressed mood most of the day, nearly every day, as indicated by either subjective report [e.g., feels sad or empty] or observation made by others [e.g., appears tearful]. [In children and adolescents, this may be characterized as an irritable mood.] Markedly diminished interest or pleasure in all, or almost all, activities most […]
In the last post, I spoke of the blurring of boundaries between research and clinical medicine in psychiatry over the last twenty-five years in reference to Dr. Darrel Regier’s bizarre comment, "… that’s what the DSM is – a set of scientific hypotheses that are intended to be tested and disproved if the evidence isn’t […]
Since Dr. Allen Frances seems to have taken a well-deserve holiday, I thought I’d revive one of his older posts: DSM 5 – ‘Living Document’ or ‘Dead on Arrival’ untested ‘scientific hypotheses’ must be dropped Psychology Today by Allen J. Frances, M.D. November 11, 2011 News flash From Medscape Medical News – ‘APA Answers DSM-5 […]
TO: The DSM-5 Task Force FROM: 1boringoldman RE: The DSM-5 Revisions The APA’s responses to criticisms of the DSM-5 Task Force have changed over the last several years. The 2009 article [Setting the Record Straight: A Response to Frances Commentary on DSM-V] was a contentious ad hominem attack on the motives of their critics, Drs. […]
If you have any more energy for Latuda®, there’s another study[ies] coming soon to a journal near you. A year ago, Sunovion announced another six week schizophrenia trial [80mg, 160mg] against comparator Quetiapine [Seroquel®] 600mg XR. But that was just a prequel to a one year study to look at relapse rates. In October, Sunovion […]
This Latuda® story took some downward turns along the way. It started for me with an article in the American Journal of Psychiatry [Lurasidone in the treatment of schizophrenia: a randomized, double-blind, placebo- and olanzapine-controlled study]. When I looked at the FDA approval data, the study that the article reported on looked a lot weaker […]
Looking at the timeline on my last post, I got confused myself. Here’s another attempt showing: DATE, CLINICAL TRIAL D1050231, FDA, AJP [article history], OTHER [presentations], MERGER [Dianippon Sumitomo Pharma & Sepracor]: Latuda® DATE CLINICAL TRIAL D1050231 FDA AJP OTHER MERGER SPONSOR STATUS STUDY P.I. AGENCY 02/13/08 DSP Recruiting Sonnenberg Uptown DSP Sepracor […]