lame…

Posted on Saturday 17 March 2012


In their article, “A Comparison of DSM-IV and DSM-5 Panel Members’ Financial Associations with Industry: A Pernicious Problem Persists,” which appeared in the March issue of the journal Public Library of Science, and which ABC and other news outlets quoted, Cosgrove and Krimsky question the work of DSM-5’s volunteer Task Force and Work Group members because of publicly disclosed relationships with the pharmaceutical industry. Although we appreciate that Cosgrove and Krimsky acknowledge the commitment the American Psychiatric Association (APA) has already made to reducing potential financial conflicts of interest, we strongly disagree with their analysis and presentation of APA’s publicly available disclosure documents. Specifically, the Cosgrove-Krimsky article does not take into account the level to which DSM-5 Task Force and Work Group members have minimized or divested themselves from relationships with the pharmaceutical industry.

In 2012, 72 percent of the 153 members report no relationships with the pharmaceutical industry during the previous year. The scope of the relationships reported by the other 28 percent of member varies:

  • 12 percent reported grant support only, including funding or receipt of medications for clinical trial research;
  • 10 percent reported consultations including advice on the development of new compounds to improve treatments; and
  • 7 percent reported receiving honoraria.
Additionally, since there were no disclosure requirements for journals, symposia or the DSM-IV Task Force at the time of the 1994 release of DSM-IV, Cosgrove and Krimsky’s comparison of DSM-IV and DSM-5 Task Force and Work Group members is not valid. In assembling the DSM-5’s Task Force and Work Groups, the APA’s Board of Trustees developed an extensive process of written disclosure of potential conflicts of interest. These disclosures are required of all professionals who participate in the development of DSM-5. An independent APA committee reviews these disclosure documents, which are updated annually or whenever a member’s financial interests change. Individuals are only permitted to serve on a work group or the Task Force if they are judged to have no significant financial interests.

The Board of Trustees’ guiding principles and disclosure policies for DSM panel members require annual disclosure of any competing interests or potentially conflicting relationships with entities that have an interest in psychiatric diagnoses and treatments. In addition, all Task Force and Work Group members agreed that, starting in 2007 and continuing for the duration of their work on DSM-5, each member’s total annual income derived from industry sources would not exceed $10,000 in any calendar year. This standard is more stringent than requirements for employees at the National Institutes of Health and for members of advisory committees for the Food and Drug Administration. And since their participation in DSM-5 began, many Task Force members have gone to greater lengths by terminating many of their industry relationships.

Potential financial conflicts of interest are serious concerns that merit careful, ongoing monitoring. The APA remains committed to reducing potential bias and conflicts of interest through our stringent guidelines.

"Specifically, the Cosgrove-Krimsky article does not take into account the level to which DSM-5 Task Force and Work Group members have minimized or divested themselves from relationships with the pharmaceutical industry." So the Workgroup members dropped their financial ties during 2011 when they were working on the DSM-5. So what? Does Dr. Oldham really want to nit-pick about that point? Does dropping industry connections in order to look pristine during the time of the revision expunge the impact of those industry connections? or the impact of the fact that you’re a person who would have industry connections in the first place? or reassure us that the DSM-5 as it’s being presented to us is uninfluenced by the pharmaceutical industry?

Frankly, I find Oldham’s letter as indicting as the article by Cosgrove and Krimsky [A Comparison of DSM-IV and DSM-5 Panel Members’ Financial Associations with Industry: A Pernicious Problem Persists]. It’s another APA "Is not!" response – their standard M.O. from the get go. It’s about as reassuring as, "In a statement, APA medical director and ceo James Scully says the DSM-5 development process ‘is the most open and transparent of any previous edition of the DSM. We wanted to include a wide variety of scientists and researchers with a range of expertise and viewpoints in the DSM-5 process. Excluding everyone with direct or indirect funding from the industry would unreasonably limit the participation of leading mental health experts in the DSM-5 development process.’" It’s ludicrous to say in 2012 that the rampant pharmaceutical industry connections with psychiatry’s top eschelon is not a problem. It’s a huge problem. A show stopper! A blockbuster! Finding a way to meet the letter of the law doesn’t solve it. It just makes us feel like you think we’re idiots and would believe anything…
  1.  
    Tom
    March 17, 2012 | 8:56 AM
     

    Oldham is certainly an old ham: Note that he says 72 percent of the Task Force had no ties to Pharma in the last year…. Big Deal! They are still married to the Mob so to speak. And when their work is done they will jump right back in bed with Pharma and laugh all the way to the bank.

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